CAJ | 학술논문

目的：观察中药加味芍药甘草汤对慢性萎缩性胃炎（ CAG）模型大鼠的治疗作用，并探讨其作用机制。方法采用化学致癌物N-甲基-N′-硝基-N-亚硝基胍（ MNNG）建立CAG大鼠模型，以三九胃泰为对照组，加味芍药甘草汤治疗90 d 后观察胃黏膜炎症情况，检测大鼠胃黏膜血流量（ GMBF ）、胃黏膜超氧化物歧化酶（ SOD ）活力、谷胱甘肽（ GSH-Px ）活力及丙二醛（ MDA）含量。结果加味芍药甘草汤高、中剂量组大鼠胃黏膜组织学接近正常组。与模型组相比，加味芍药甘草汤各剂量组大鼠胃黏膜SOD、GSH-Px显著升高，MDA显著降低，GMBF 显著增高。结论加味芍药甘草汤对慢性萎缩性胃炎模型大鼠胃黏膜有一定保护作用，能改善和逆转实验性慢性萎缩性胃炎大鼠胃黏膜萎缩。其机制可能与其增加胃黏膜血流量、增强胃黏膜屏障功能、抗自由基损伤等有关。
목적：관찰중약가미작약감초탕대만성위축성위염（ CAG）모형대서적치료작용，병탐토기작용궤제。방법채용화학치암물N-갑기-N′-초기-N-아초기고（ MNNG）건립CAG대서모형，이삼구위태위대조조，가미작약감초탕치료90 d 후관찰위점막염증정황，검측대서위점막혈류량（ GMBF ）、위점막초양화물기화매（ SOD ）활력、곡광감태（ GSH-Px ）활력급병이철（ MDA）함량。결과가미작약감초탕고、중제량조대서위점막조직학접근정상조。여모형조상비，가미작약감초탕각제량조대서위점막SOD、GSH-Px현저승고，MDA현저강저，GMBF 현저증고。결론가미작약감초탕대만성위축성위염모형대서위점막유일정보호작용，능개선화역전실험성만성위축성위염대서위점막위축。기궤제가능여기증가위점막혈류량、증강위점막병장공능、항자유기손상등유관。
Objective To study the function of Modified Shaoyao Gancao decoction on treating Chronic Atrophic Gastritis ( CAG) mod-el rats and investigate its mechanism.Methods CAG rat models were established by means of N-methyl-N′-nitro-N-nitrosoguanidine ( MNNG) ,and the effect of Modified Shaoyao Gancao Decoction on the gastric mucosa infIammation and gastric atrophy level, the gas-tric mucosal blood flow ( GMBF) , the change of glutathione( GSH-Px) ,superoxide dismutas( SOD) and malonyl dialdehyd( MDA) con-tents were observed and compared with that of Sanjiu Weitai particles.Results There is no significant difference of gastric mucosal histology features between high-dosage, medium-dosage groups of the Modified Shaoyao Gancao Decoction with the normal control group.Compared to model group.Modified Shaoyao Gancao Decoction has made a significant increase of SOD ,GSH-Px in the CAG rats,and can make the levels of MDA decrease significantly, and can make a significant increase of GMBF(P<0.05,P<0.01).Con-clusion The Modified Shaoyao Gancao Decoction has good curative effect to chronic atrophic gastritic model rats,and it can also im-prove and reverse the gastric atrophy of experimental atrophic gastritis of rats.Its mechanism maybe related to improving blood circula-tion of gastric mucosa,strengthening gastric mucosal protective screen and resisting the free radical impairment and so on.