蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2015年
8期
992-993,994
,共3页
朱云琳%程新德%梅娟%马红丽%张莉
硃雲琳%程新德%梅娟%馬紅麗%張莉
주운림%정신덕%매연%마홍려%장리
外科皮瓣%川芎嗪%兔
外科皮瓣%川芎嗪%兔
외과피판%천궁진%토
skin flap%ligustrazine%rabbit
目的::寻找川芎嗪对缺血皮瓣发挥保护作用的合适剂量。方法:家兔16只随机分为4组,于兔背部设计8 cm ×2 cm任意皮瓣,切取、剥离后原位缝合。对照组(A组)予以0.9%氯化钠注射液4 ml/kg,术后用药组分别予以川芎嗪15、30、60 mg/kg( B、C、D组)。术后第7天处死白兔,测量皮瓣成活面积,分析不同剂量的川芎嗪与皮瓣成活之间的关系。结果:术后第7天皮瓣远端均发生坏死,近端成活。随药物剂量增加,C、D组皮瓣成活面积及成活率均高于A、B组( P<0.05~P<0.01);A组与B组和C组与D组皮瓣成活面积及成活率差异均无统计学意义(P>0.05)。结论:适当剂量使用川芎嗪治疗可提高局部缺血皮瓣的成活率。
目的::尋找川芎嗪對缺血皮瓣髮揮保護作用的閤適劑量。方法:傢兔16隻隨機分為4組,于兔揹部設計8 cm ×2 cm任意皮瓣,切取、剝離後原位縫閤。對照組(A組)予以0.9%氯化鈉註射液4 ml/kg,術後用藥組分彆予以川芎嗪15、30、60 mg/kg( B、C、D組)。術後第7天處死白兔,測量皮瓣成活麵積,分析不同劑量的川芎嗪與皮瓣成活之間的關繫。結果:術後第7天皮瓣遠耑均髮生壞死,近耑成活。隨藥物劑量增加,C、D組皮瓣成活麵積及成活率均高于A、B組( P<0.05~P<0.01);A組與B組和C組與D組皮瓣成活麵積及成活率差異均無統計學意義(P>0.05)。結論:適噹劑量使用川芎嗪治療可提高跼部缺血皮瓣的成活率。
목적::심조천궁진대결혈피판발휘보호작용적합괄제량。방법:가토16지수궤분위4조,우토배부설계8 cm ×2 cm임의피판,절취、박리후원위봉합。대조조(A조)여이0.9%록화납주사액4 ml/kg,술후용약조분별여이천궁진15、30、60 mg/kg( B、C、D조)。술후제7천처사백토,측량피판성활면적,분석불동제량적천궁진여피판성활지간적관계。결과:술후제7천피판원단균발생배사,근단성활。수약물제량증가,C、D조피판성활면적급성활솔균고우A、B조( P<0.05~P<0.01);A조여B조화C조여D조피판성활면적급성활솔차이균무통계학의의(P>0.05)。결론:괄당제량사용천궁진치료가제고국부결혈피판적성활솔。
Objective:To investigate the suitable dosages of ligustrazine with good protective effect on ischemic skin flap. Methods:The Japanese big ear white rabbits were randomly divided into four groups. The 8 cm × 2 cm random flap in the rabbit back was designed,cut and stripped,and the rabbits were stitched in situ. Group B,C and D were treated with 15,30 and 60 mg/kg of ligustrazine after operation,respectively,and the group A were treatment with 4 ml/kg of 0. 9% sodium chloride injection. Rabbits were sacrificed after 7 days of operation, the flap survival area was measured, the relationship between different concentrations ligustrazine and flap survival was analyzed. Results:The distal necrosis and proximal survival of flap was found after days 7 operation. With the increasing of drug dosages,the flap survival area and average survival rate increased. The flap survival area and average survival in group C and D were higher than those in group A and B(P<0. 05 to P<0. 01),the differences of which between group A and B,and between group C and D were not statistically significant(P >0. 05). Conclusions:Appropriate dose of ligustrazine can improve the survival rate of ischemic skin flap.