CAJ | 학술논문

机体正常生理功能的调节是由特定时间和特定部位瞬间释放的生物活性物质所控制的。脉冲释药系统是根据疾病的昼夜节律特点，并遵循时辰药理学原理在最佳时间释放药物，达到最佳疗效和最低毒副作用的一种释药模型。近几年，脉冲微丸以无剂量突释、可预测的胃排空时间、灵活的释药模式和较高的生物利用度的特点受到越来越多的关注。本文主要介绍脉冲微丸的设计原理及其研究进展。
궤체정상생리공능적조절시유특정시간화특정부위순간석방적생물활성물질소공제적。맥충석약계통시근거질병적주야절률특점，병준순시신약이학원리재최가시간석방약물，체도최가료효화최저독부작용적일충석약모형。근궤년，맥충미환이무제량돌석、가예측적위배공시간、령활적석약모식화교고적생물이용도적특점수도월래월다적관주。본문주요개소맥충미환적설계원리급기연구진전。
Under physiological conditions, many vital functions of the body are controlled by transient release of bioactive substances at a specific time and site. Based on the circadian rhythm character of disease and chronotherapeutic conceptions, pulsatile delivery system has been designed to achieve optimal therapeutic effect and reduce the toxic and side-effect. In recent years, more and more studies are focused on the pulsatile multiparticulate drug delivery system. Pulsatile multiparticulate system possesses many benefits, such as no risk of dose dumping, predictable gastric emptying, flexible release patterns and increased bioavailability. Based on these premises, the aim of this review is to summarize the major design methods of pulsatile multiparticulate and the research progress.