CAJ | 학술논문

聚乙烯亚胺（yethylenimine，PEI）是目前比较有前途的非病毒基因载体之一。载体靶向性或特异性是理想基因载体系统的主要特性，但是高相对分子质量的PEI毒性较大且缺乏肿瘤靶向性，因此，需要对PEI进行改造，使其成为一种具有靶向性的低毒性基因载体。目前关于PEI被修饰成为靶向性基因导入载体已有许多研究，主要包括：①以转铁蛋白、RGD肽等内源性配体的修饰；②以半乳糖等碳水化合物的修饰；③特异性抗体修饰。其中，以抗体作为靶向元件进行修饰，构建抗体靶向的PEI具有独特优势和发展前景。本文综述近年来国内外关于靶向性PEI基因导入载体的研究现状。
취을희아알（yethylenimine，PEI）시목전비교유전도적비병독기인재체지일。재체파향성혹특이성시이상기인재체계통적주요특성，단시고상대분자질량적PEI독성교대차결핍종류파향성，인차，수요대PEI진행개조，사기성위일충구유파향성적저독성기인재체。목전관우PEI피수식성위파향성기인도입재체이유허다연구，주요포괄：①이전철단백、RGD태등내원성배체적수식；②이반유당등탄수화합물적수식；③특이성항체수식。기중，이항체작위파향원건진행수식，구건항체파향적PEI구유독특우세화발전전경。본문종술근년래국내외관우파향성PEI기인도입재체적연구현상。
Currently, polyethylenimine(PEI) is one of the most promising non-viral gene delivery vectors. However, high relative molecular mass PEI has obvious toxicity and is short of targeting or specificity to cells or tissues. As we know, targeting or specificity is the key property of ideal gene delivery systems. Therefore, PEI should be modified to become a gene vector with targeting and low toxicity. Up to now, investgations on modification of PEI for targeting effect mainly include:1.modification with endogenous ligands such as transferrin(Tf),RGD peptide, etc;2.modification with carbohydrate such as galactose,etc;3.modification with specific antibody. Of these, the specific antibody-directed PEI is anticipated to be one of promising and distinctive targeting gene delivery carriers. The present paper summarises literature on PEI as targeted gene delivery vectors.