CAJ | 학술논문

目的：对糖尿病肾病患者血清β2微球蛋白检验的临床价值进行评价分析，为今后的临床检验工作提供有价值的参考信息。方法抽取2013年5月～2015年5月我院收治的获得临床明确诊断的糖尿病患者199例，其中糖尿病肾病患者79例，定义为观察组，无肾病、酮症酸中毒、严重心肝肾疾病糖尿病者120例，定义为对照组，另抽取同期健康体检者60例作为健康组。对这三组受试者展开血清β2微球蛋白检验，并对检验结果进行对比分析。结果观察组患者血清β2微球蛋白水平与异常率较对照组和健康组比较升高（P<0.05）；糖尿病肾病患者病程≥5年者血清β2微球蛋白水平及异常率较病程＜5年者升高（P<0.05）。结论血清β2微球蛋白在糖尿病肾病早期诊断中具有重要意义，可作为一项重要的敏感指标。
목적：대당뇨병신병환자혈청β2미구단백검험적림상개치진행평개분석，위금후적림상검험공작제공유개치적삼고신식。방법추취2013년5월～2015년5월아원수치적획득림상명학진단적당뇨병환자199례，기중당뇨병신병환자79례，정의위관찰조，무신병、동증산중독、엄중심간신질병당뇨병자120례，정의위대조조，령추취동기건강체검자60례작위건강조。대저삼조수시자전개혈청β2미구단백검험，병대검험결과진행대비분석。결과관찰조환자혈청β2미구단백수평여이상솔교대조조화건강조비교승고（P<0.05）；당뇨병신병환자병정≥5년자혈청β2미구단백수평급이상솔교병정＜5년자승고（P<0.05）。결론혈청β2미구단백재당뇨병신병조기진단중구유중요의의，가작위일항중요적민감지표。
Objective Clinical value of serum β2 microglobulin test was evaluated in patients with diabetic nephropathy analysis provides valuable reference information for future clinical laboratory work.Methods Extraction between May 2013 to May 2015 in our hospital to obtain the clinical diagnosis of diabetes 199 cases,including 79 cases of patients with diabetic nephropathy,defined as the observation group,without nephropathy,ketoacidosis, severe heart and liver 120 cases of diabetic kidney disease,defined as a control group,and the other to extract the same period 60 cases of healthy people as a health group. Expand these three groups of subjects serum β2 microglobulin inspection,and test results were analyzed.ResultsThere were abnormal serum β2microglobulin rate than the control group and the healthy group were significantly increased(P< 0.05)compare occurrence, duration of diabetes,kidney disease≥5 years serum β2-microglobulin levels and abnormal rate than duration< 5 years was significantly increased(P< 0.05). ConclusionSerum β2-microglobulin is important in the early diagnosis of diabetic nephropathy can be used as a sensitive indicator of an important concern.