CAJ | 학술논문

随着现代医学的发展，抗真菌药物广泛应用，白假丝酵母（又称白念珠菌）耐药现象日益严重。由酵母相转变为菌丝相是白念珠菌致病的一个必要过程，抑制菌丝形成可控制其感染。细菌群体感应信号分子BDSF （顺十二碳‐2‐烯酸）可抑制这一形态的转变，从而抑制白念珠菌的致病力。本研究检测BDSF对60株白念珠菌临床菌株的抑菌丝效果，同时测定这60株临床菌株对氟康唑的敏感度。结果显示，60株临床菌株中8株（13．3％）对氟康唑耐药，最低抑菌浓度（MIC ）≥64μg／ml ，而BDSF对耐与不耐氟康唑的临床菌株均能高效抑制菌丝生长。结果表明，BDSF可作为临床治疗白念珠菌感染的新型候选药物，值得进一步研究。
수착현대의학적발전，항진균약물엄범응용，백가사효모（우칭백념주균）내약현상일익엄중。유효모상전변위균사상시백념주균치병적일개필요과정，억제균사형성가공제기감염。세균군체감응신호분자BDSF （순십이탄‐2‐희산）가억제저일형태적전변，종이억제백념주균적치병력。본연구검측BDSF대60주백념주균림상균주적억균사효과，동시측정저60주림상균주대불강서적민감도。결과현시，60주림상균주중8주（13．3％）대불강서내약，최저억균농도（MIC ）≥64μg／ml ，이BDSF대내여불내불강서적림상균주균능고효억제균사생장。결과표명，BDSF가작위림상치료백념주균감염적신형후선약물，치득진일보연구。
The drug resistance of Candida albicans ( C . albicans ) , resulted from gradual application of advanced medical treatments and the widespread use of antifungals ,has become a severe problem in clinic . C . albicans is one of the major opportunistic human fungal pathogens .The transition from yeast to hypha is a necessary process in its pathogenic activity ,and inhibiting the hypha formation can decrease its infective ability .Quorum sensing signal BDSF (short‐chain fatty acid) from Burkholderiacenocepacia can inhibit the yeast‐to‐hypha transition and hinder the virulence of C . albicans .The drug susceptibility of 60 C . albicans clinical isolates to fluconazole and BDSF were determined respectively . The results showed there were 8 strains (13 .3% ) resistant to fluconazole ,with the minimum inhibitory concentration (MIC) ≥64 μg/ml , but BDSF showed efficiently inhibitory effect on all the clinical isolates no matter the isolates were resistant to fluconazole or not .The results suggest that BDSF might be a new clinical option to treat C . albicans infection .