CAJ | 학술논문

目的：分析妊娠期急性脂肪肝(AFLP)的临床特征及其终止妊娠时间对母儿预后产生的影响。方法收集我院2011年10月至2013年10月期间诊治的妊娠期急性脂肪肝患者120例作为研究对象，按照不同的诊断及分娩时间将患者分为A组、B组和C组，A组为确诊后1 d以内终止妊娠，共计40例，B组为确诊后1~2 d终止妊娠，共计30例，C组为确诊后2 d超过2 d终止妊娠组，共计50例，回顾性分析患者的临床资料。结果研究结果显示，B、C两组急性肾功能衰竭发生率、24 h尿蛋白超过3 g的比率明显高于A组，数据比较差异具有统计学意义(P＜0.01)；C组弥散性血管内凝血发生率、孕产妇病死率、新生儿窒息率及围生儿病死率明显高于A组，数据比较差异具有统计学意义(P＜0.05)；三组急性脂肪肝孕产妇阴道分娩率、剖宫产分娩率比较具有明显差异(P＜0.05)。结论妊娠期急性脂肪肝一旦确诊应及时的处理，在确诊后48 h内终止妊娠可减少母婴预后的影响。
목적：분석임신기급성지방간(AFLP)적림상특정급기종지임신시간대모인예후산생적영향。방법수집아원2011년10월지2013년10월기간진치적임신기급성지방간환자120례작위연구대상，안조불동적진단급분면시간장환자분위A조、B조화C조，A조위학진후1 d이내종지임신，공계40례，B조위학진후1~2 d종지임신，공계30례，C조위학진후2 d초과2 d종지임신조，공계50례，회고성분석환자적림상자료。결과연구결과현시，B、C량조급성신공능쇠갈발생솔、24 h뇨단백초과3 g적비솔명현고우A조，수거비교차이구유통계학의의(P＜0.01)；C조미산성혈관내응혈발생솔、잉산부병사솔、신생인질식솔급위생인병사솔명현고우A조，수거비교차이구유통계학의의(P＜0.05)；삼조급성지방간잉산부음도분면솔、부궁산분면솔비교구유명현차이(P＜0.05)。결론임신기급성지방간일단학진응급시적처리，재학진후48 h내종지임신가감소모영예후적영향。
Objective To analyze the clinical features of acute fatty liver (markers) during pregnancy and its termination time mother to son prognostic impact. Methods Collected from October 2011 to October 2013, during the treatment period, 120 patients with acute fatty liver of pregnancy as the research object, according to the patients with different diagnosis and delivery time will be divided into group A and group B and group C, group A to diagnose the pregnancy is terminated within one day, A total of 40 cases of group B is confirmed after 1 d or 2 d termination of pregnancy, A total of 30 cases, group C for two days more than two days after diagnosis to terminate pregnancy group, A total of 50 cases, the clinical data of patients were retrospectively analyzed. Results The results showed that B and C in the two groups the incidence of acute renal failure, 24 hours urine protein more than 3 g was significantly higher than that of group A, data comparison differences statistically significant (P<0.01);Group C diffuse intravascular coagulation rate, maternal mortality, neonatal asphyxia rate and perinatal mortality is significantly higher than group A, data comparison differences statistically significant (P<0.05);Three groups of acute fatty liver of maternal vaginal births, cesarean births has the obvious difference (P<0.05). Conclusion Pregnancy once diagnosed acute fatty liver should be dealt with in a timely manner, in the pregnancy is terminated within 48 hours after diagnosis can reduce the influence of maternal and infant prognosis.