CAJ | 학술논문

摄食抑制因子Nesfatin-1是由核组蛋白NUCB2的N端水解产生的由82个氨基酸组成的肽段。自2006年日本Oh-I教授首次报道Nesfatin-1广泛表达于下丘脑以来，关于其生理功能的研究不断深入。近期研究表明，除了参与摄食及能量代谢的调节之外， Nesfatin-1还参与情绪反应的中枢调控，与抑郁症的发生密切相关。该文就Nesfatin-1的分布及其在抑郁症发病机制的作用做一综述，旨在明确Nesfatin-1的生理功能，也为进一步揭示抑郁症的发病机制提供依据。
섭식억제인자Nesfatin-1시유핵조단백NUCB2적N단수해산생적유82개안기산조성적태단。자2006년일본Oh-I교수수차보도Nesfatin-1엄범표체우하구뇌이래，관우기생리공능적연구불단심입。근기연구표명，제료삼여섭식급능량대사적조절지외， Nesfatin-1환삼여정서반응적중추조공，여억욱증적발생밀절상관。해문취Nesfatin-1적분포급기재억욱증발병궤제적작용주일종술，지재명학Nesfatin-1적생리공능，야위진일보게시억욱증적발병궤제제공의거。
Nesfatin-1, discovered in 2006 by Oh-I as an 82-ami-no-acid peptide derived from the precursor protein nucleobindin2 (NUCB2), has been identified to play an important role in the regulation of food intake and energy metabolism. Recently, it has also been found that Nesfatin-1 might be associated with the pathogenesis of depression. This article reviewed the advances in related studies on Nesfatin-1 at home and abroad, which should throw light in expliciting the physiological function of Nesfatin-1 and understanding the neurobiological mechanism of depression.