CAJ | 학술논문

目的：探究运动训练对海马形态、结构及其功能的干预效果及其分子机制。方法：通过文献资料法对运动训练影响大脑海马神经元的形态变化和生理功能的发挥及其各生理因子信号通路的研究进展进行综合分析。结果：发现运动训练可以通过影响神经营养因子而增加海马神经元突触的蛋白含量和树突的长度及密度，进而改善大脑海马的生理功能，降低各种神经退行性疾病的发生率。结论：运动训练可以改善海马结构并有效延缓其机体功能的退行性变化，其作用机制可能与 FMRP突变通过 DGCR8基因3′UTR相互作用下调报告基因表达有关。
목적：탐구운동훈련대해마형태、결구급기공능적간예효과급기분자궤제。방법：통과문헌자료법대운동훈련영향대뇌해마신경원적형태변화화생리공능적발휘급기각생리인자신호통로적연구진전진행종합분석。결과：발현운동훈련가이통과영향신경영양인자이증가해마신경원돌촉적단백함량화수돌적장도급밀도，진이개선대뇌해마적생리공능，강저각충신경퇴행성질병적발생솔。결론：운동훈련가이개선해마결구병유효연완기궤체공능적퇴행성변화，기작용궤제가능여 FMRP돌변통과 DGCR8기인3′UTR상호작용하조보고기인표체유관。
To investigate the intervention effect of exercise training on the structure and function of hippocampus morphology, and its molecular mechanism. The research methods: by consulting a large number of domestic and foreign literatures to make the comprehensive analysis about the research progress on effect the morphology changes of hippocampus neurons and the exertion of physiological function and each physiological factor of signaling pathways. The result:finding that exercise training can influence brain-derived neurotrophic factor(BDNF) and increase the protein content of hippocampus neuron synapses and dendrites’ length and density, and improve brain hippocampus physiological function, reduce the incidence of various neurodegenerative diseases. The conclusion:Exercise training can improve the function of hippocampus structure and delay the degenerative changes of the body function, and its mechanism may be related to FMRP mutation by DGCR8 gene 3 'UTR cut report gene expression related interactions.