中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2015年
22期
1-1,3
,共2页
韩迎莉%王跃玲%郭雯%张娜%邵莎苑%徐丽%张宏%杨瑞生
韓迎莉%王躍玲%郭雯%張娜%邵莎苑%徐麗%張宏%楊瑞生
한영리%왕약령%곽문%장나%소사원%서려%장굉%양서생
血清缺血修饰白蛋白%急性冠状动脉综合征%心肌缺血
血清缺血脩飾白蛋白%急性冠狀動脈綜閤徵%心肌缺血
혈청결혈수식백단백%급성관상동맥종합정%심기결혈
Serum ischemia modiifed albumin%Acute coronary syndrome%Myocardial ischemia
目的：探讨血清缺血修饰白蛋白（IMA）在诊断急性冠状动脉综合征中的应用价值。方法随机选取2014年至2015年因怀疑急性冠状动脉综合征而收治入河南大学第一附属医院心内科且拟行冠状动脉造影术的患者100例。行造影前均接受IMA、肌钙蛋白（cTnT）、血脂、血压及心电图（ECG）检测；以造影结果为标准将入组患者分为冠心病组和非冠心病组。分析IMA对冠心病心肌缺血诊断的价值，诊断价值采用受试者工作特征曲线(ROC曲线)下面积(AUC)以及logistic回归分析。结果冠心病组患者的平均IMA水平[(91±27)U/mL]较非冠心病组患者的平均IMA水平[(59±21)U/mL]明显升高。当Cut-off值为77.53 U/mL时，其诊断冠心病心肌缺血的价值最大，敏感度、特异度、阳性预测值、阴性预测值分别为88.1%、36.4%、74.7%、57.1%。而同步测定cTnT真阳性者为39例，敏感度为58.2%。结论 IMA是诊断急性冠状动脉综合征的早期敏感指标。
目的：探討血清缺血脩飾白蛋白（IMA）在診斷急性冠狀動脈綜閤徵中的應用價值。方法隨機選取2014年至2015年因懷疑急性冠狀動脈綜閤徵而收治入河南大學第一附屬醫院心內科且擬行冠狀動脈造影術的患者100例。行造影前均接受IMA、肌鈣蛋白（cTnT）、血脂、血壓及心電圖（ECG）檢測；以造影結果為標準將入組患者分為冠心病組和非冠心病組。分析IMA對冠心病心肌缺血診斷的價值，診斷價值採用受試者工作特徵麯線(ROC麯線)下麵積(AUC)以及logistic迴歸分析。結果冠心病組患者的平均IMA水平[(91±27)U/mL]較非冠心病組患者的平均IMA水平[(59±21)U/mL]明顯升高。噹Cut-off值為77.53 U/mL時，其診斷冠心病心肌缺血的價值最大，敏感度、特異度、暘性預測值、陰性預測值分彆為88.1%、36.4%、74.7%、57.1%。而同步測定cTnT真暘性者為39例，敏感度為58.2%。結論 IMA是診斷急性冠狀動脈綜閤徵的早期敏感指標。
목적：탐토혈청결혈수식백단백（IMA）재진단급성관상동맥종합정중적응용개치。방법수궤선취2014년지2015년인부의급성관상동맥종합정이수치입하남대학제일부속의원심내과차의행관상동맥조영술적환자100례。행조영전균접수IMA、기개단백（cTnT）、혈지、혈압급심전도（ECG）검측；이조영결과위표준장입조환자분위관심병조화비관심병조。분석IMA대관심병심기결혈진단적개치，진단개치채용수시자공작특정곡선(ROC곡선)하면적(AUC)이급logistic회귀분석。결과관심병조환자적평균IMA수평[(91±27)U/mL]교비관심병조환자적평균IMA수평[(59±21)U/mL]명현승고。당Cut-off치위77.53 U/mL시，기진단관심병심기결혈적개치최대，민감도、특이도、양성예측치、음성예측치분별위88.1%、36.4%、74.7%、57.1%。이동보측정cTnT진양성자위39례，민감도위58.2%。결론 IMA시진단급성관상동맥종합정적조기민감지표。
Objective To investigate the application value of serum ischemia modiifed albumin (IMA) in diagnosis of acute coronary syndrome. Methods Randomly selected 100 cases of patients undergoing coronary angiography of suspicion of acute coronary syndrome and admitted to the department of cardiology, the First Afifliated Hospital of Henan University in 2014-2015 years. IMA, troponin (cTnT), blood lipid, blood pressure and electrocardiogram (ECG) were detected before angiography. The patients were divided into the coronary heart disease group and the non CHD group by the results of the angiography. To analyze the value of IMA in the diagnosis of myocardial ischemia in patients with coronary heart disease, the diagnostic value was analyzed by the area (AUC) of ROC curve and Logistic regression analysis. Results The level of IMA in patients with CHD[(97±27)U/mL] was signiifcantly higher than that in non CHD[(59±21)U/mL] controls. When the cut-off value of IMA was77.53 U/mL,the sensitivity,speciifcity and both positive and negative predictive values of IMA were 88.1%, 36.4%, 74.7%and 57.1%respectively. The value of IMA in diagnosis of coronary heart disease myocardial ischemia is the largest, the sensitivity rate was 58.2%. Meanwhile, the value in only 39 patients was positive with cTnT. Conclusions IMA is an early sensitive index for diagnosis of acute coronary syndrome(ACS).
