CAJ | 학술논문

目的：制备盐酸洛美沙星乳膏剂并建立含量测定方法。方法盐酸洛美沙星为主药，采用高效液相色谱法测定制剂中盐酸洛美沙星的含量。结果盐酸洛美沙星在12~28μg·mL -1范围内呈良好的线性关系，A =-1.7476×104+6.5344×104 C（r =0.9998），平均回收率99.74%；RSD 为0.39%。结论该乳膏剂处方合理，制备工艺简单，含量测定方法操作简单，结果准确。
목적：제비염산락미사성유고제병건립함량측정방법。방법염산락미사성위주약，채용고효액상색보법측정제제중염산락미사성적함량。결과염산락미사성재12~28μg·mL -1범위내정량호적선성관계，A =-1.7476×104+6.5344×104 C（r =0.9998），평균회수솔99.74%；RSD 위0.39%。결론해유고제처방합리，제비공예간단，함량측정방법조작간단，결과준학。
Objective To prepare Lomefloxacin Hydrochloride Cream and establish the determination meth-od. Methods Lomefloxacin hydrochloride as main medicine,its content was determinated by HPLC. Results The lome-floxacin hydrochloride showed a good linear relationship in 12 ~ 28 μg·mL - 1 ,A = - 1. 747 6 × 104 + 6. 534 4 × 104 C(r =0. 999 8),the average recovery was 99. 74% with RSD of 0. 39%. Conclusion The prescription was reasonable and prep-aration technological was easy. The method of determination was simple and accurate.