CAJ | 학술논문

目的：探讨人绒毛膜促性腺激素（HCG）治疗子宫内膜异位症大鼠的疗效及机制。方法：诱导法成功建立子宫内膜异位症大鼠模型24只，随机分为4组，每组6只，分别以每天19．4 IU／100 g（HCG低剂量组）、25．8 IU／100 g（HCG中剂量组）和51．6 IU／100 g（HCG高剂量组）的HCG治疗15 d，并以生理盐水作为对照，比较各组治疗前后异位病灶体积的变化及异位内膜、在位内膜电镜下超微结构的改变。结果：HCG治疗后，HCG低、中和高剂量组的异位病灶体积均较治疗前减小（P＜0．05）；治疗前子宫内膜和异位内膜胞浆内可见大量线粒体、内质网及核糖体；治疗后部分细胞结构不清，部分线粒体嵴减少或消失，细胞致密、萎缩，胞浆中自噬体增多，线粒体和内质网肿胀。结论：HCG可能使在位和异位内膜中的细胞功能代谢减退，从而对子宫内膜异位症大鼠有治疗作用。
목적：탐토인융모막촉성선격소（HCG）치료자궁내막이위증대서적료효급궤제。방법：유도법성공건립자궁내막이위증대서모형24지，수궤분위4조，매조6지，분별이매천19．4 IU／100 g（HCG저제량조）、25．8 IU／100 g（HCG중제량조）화51．6 IU／100 g（HCG고제량조）적HCG치료15 d，병이생리염수작위대조，비교각조치료전후이위병조체적적변화급이위내막、재위내막전경하초미결구적개변。결과：HCG치료후，HCG저、중화고제량조적이위병조체적균교치료전감소（P＜0．05）；치료전자궁내막화이위내막포장내가견대량선립체、내질망급핵당체；치료후부분세포결구불청，부분선립체척감소혹소실，세포치밀、위축，포장중자서체증다，선립체화내질망종창。결론：HCG가능사재위화이위내막중적세포공능대사감퇴，종이대자궁내막이위증대서유치료작용。
AIM:Toinvestigatewhetherandhowhumanchorionicgonadotropin(HCG)treatmentameliorates endometriosis in the endometriotic rat model .METHODS:The rat model of endometriosis was established and the model rats were divided into 4 groups.The rats in HCG groups were treated with 19.4, 25.8 and 51.6 IU/100 g of HCG every day (low-dose HCG, medium-dose HCG and high-dose HCG, respectively).The rats in control group were treated with 0.9%NaCl.After 15 days (3 estrous cycles), the ectopic lesion volume and ultrastructural characteristics in eutopic and ectopic endometria were investigated .RESULTS: After HCG treatment , the volume of endometriotic lesions was signifi-cantly smaller than that before treatment .Numerous and mitochondrial , endoplasmic reticulum and ribosomes were ob-served in the cytoplasm of eutopic and ectopic endometrium before treatment .After treatment , some cell structures were not clear , and mitochondrial cristae decreased or disappeared partly .Some cells were densed and shrinkage , autophagosome in cytoplasm increased , and mitochondria and endoplasmic reticulum swelt .CONCLUSION:HCG therapy appears to be an effective treatment for endometriosis in rats attributed to its influence on cell metabolism dysfunction of eutopic and ectopic endometria .