CAJ | 학술논문

伊立替康广泛用于转移性结肠直肠癌的一线治疗，但其主要的不良反应是剂量相关毒性－迟发性腹泻，既影响了药物的疗效又降低了患者的体质和生活质量，甚至危及生命。因此，如何有效防治迟发性腹泻的发生有着重要的临床意义。西医药物治疗有明确疗效，但也有一定的限制性。中医中药在防止肿瘤治疗引起的不良反应方面具有独特优势，综合运用于肿瘤临床，间接地提高肿瘤治疗的缓解率并延长患者生存期，在预防和治疗伊立替康所致迟发型腹泻方面取得的疗效就是典型体现。
이립체강엄범용우전이성결장직장암적일선치료，단기주요적불량반응시제량상관독성－지발성복사，기영향료약물적료효우강저료환자적체질화생활질량，심지위급생명。인차，여하유효방치지발성복사적발생유착중요적림상의의。서의약물치료유명학료효，단야유일정적한제성。중의중약재방지종류치료인기적불량반응방면구유독특우세，종합운용우종류림상，간접지제고종류치료적완해솔병연장환자생존기，재예방화치료이립체강소치지발형복사방면취득적료효취시전형체현。
Irinotecan is widely used asthe first-line treatment of metastatic colorectal cancer.The main adverse reactions is dose-re-lated toxicity-delayed diarrhea which not only affects the drug's efficacy but also reduces the patient's physical fitness and quality of life, and even threaten their lifves.So, how to effectively prevent the occurrence of delayed diarrhea has important clinical significance. Western medicine has a clear effect of drug treatment, but there are certain limitations.Chinese medicine has a unique advantage in the prevention of adverse reactions caused by cancer treatment, with the comprehensive applicationof Clinical Oncology, indirectly improve the response rate of cancer treatment and prolong survival.The prevention and treatment of irinotecan-induced delayed diarrhea effica-cy is a typical expression.