江西中医药大学学报
江西中醫藥大學學報
강서중의약대학학보
Journal of Jiangxi University of Traditional Chinese Medicine
2015年
4期
69-71
,共3页
甘静%谢志军%邵铁娟%严余明%温成平%陈娟
甘靜%謝誌軍%邵鐵娟%嚴餘明%溫成平%陳娟
감정%사지군%소철연%엄여명%온성평%진연
青蒿-鳖甲药对%MRL/lpr小鼠%IL-6,IFN-γ%系统性红斑狼疮%狼疮性肾炎
青蒿-鱉甲藥對%MRL/lpr小鼠%IL-6,IFN-γ%繫統性紅斑狼瘡%狼瘡性腎炎
청호-별갑약대%MRL/lpr소서%IL-6,IFN-γ%계통성홍반랑창%랑창성신염
Qinghao-biejia Group%MRL/lpr mice%IL-6%IFN-γ%Systemic Lupus Erythematosus%Lupus Nephritis
目的:观察青蒿-鳖甲药对对MRL/lpr狼疮模型小鼠相关免疫指标及狼疮性肾炎( lupus nephri-tis,LN)病理改变的影响,探索青蒿-鳖甲药对对系统性红斑狼疮( systemic lupus erythematosus,SLE)的治疗机理。方法:采用ELISA方法检测小鼠血清中的IL-6、IFN-γ含量,对肾脏组织进行HE常规染色及PAS、Masson特殊染色。结果:灌胃青篙-鳖甲药对水煎液后,低、高剂量组MRL/lpr小鼠血清中的IL-6水平显著低于正常对照组(P<0.05或P<0.01);高剂量组血清中的IFN-γ水平与模型组相比,显著下降( P<0.05);高剂量组肾脏组织HE、PAS、Masson染色病理改变差异显著。结论:青蒿-鳖甲药对能抑制MRL/lpr小鼠血清中IL-6的生成,减少小鼠血清中IFN-γ的分泌,能明显改善小鼠狼疮性肾炎的病理状态。
目的:觀察青蒿-鱉甲藥對對MRL/lpr狼瘡模型小鼠相關免疫指標及狼瘡性腎炎( lupus nephri-tis,LN)病理改變的影響,探索青蒿-鱉甲藥對對繫統性紅斑狼瘡( systemic lupus erythematosus,SLE)的治療機理。方法:採用ELISA方法檢測小鼠血清中的IL-6、IFN-γ含量,對腎髒組織進行HE常規染色及PAS、Masson特殊染色。結果:灌胃青篙-鱉甲藥對水煎液後,低、高劑量組MRL/lpr小鼠血清中的IL-6水平顯著低于正常對照組(P<0.05或P<0.01);高劑量組血清中的IFN-γ水平與模型組相比,顯著下降( P<0.05);高劑量組腎髒組織HE、PAS、Masson染色病理改變差異顯著。結論:青蒿-鱉甲藥對能抑製MRL/lpr小鼠血清中IL-6的生成,減少小鼠血清中IFN-γ的分泌,能明顯改善小鼠狼瘡性腎炎的病理狀態。
목적:관찰청호-별갑약대대MRL/lpr랑창모형소서상관면역지표급랑창성신염( lupus nephri-tis,LN)병리개변적영향,탐색청호-별갑약대대계통성홍반랑창( systemic lupus erythematosus,SLE)적치료궤리。방법:채용ELISA방법검측소서혈청중적IL-6、IFN-γ함량,대신장조직진행HE상규염색급PAS、Masson특수염색。결과:관위청고-별갑약대수전액후,저、고제량조MRL/lpr소서혈청중적IL-6수평현저저우정상대조조(P<0.05혹P<0.01);고제량조혈청중적IFN-γ수평여모형조상비,현저하강( P<0.05);고제량조신장조직HE、PAS、Masson염색병리개변차이현저。결론:청호-별갑약대능억제MRL/lpr소서혈청중IL-6적생성,감소소서혈청중IFN-γ적분비,능명현개선소서랑창성신염적병리상태。
Objective:To investigate the effect of Qinghao-biejia group on auto-antibody production and pathologic change of lupus nephritis in MRL/lpr mice and the possible mechanism of qinghao-biejia group in treating systemic lupus erythematosus( SLE) .Meth-ods:IL-6 and IFN-γin serum of the MRL/lpr mice were detected by enzyme linked immunosorbent assay(ELISA).Renal tissue was stained by HE,PAS and Masson.Results:In the low and hight dose qinghao-biejia groups,as compared with the normal control group,the level of IL-6 was significantly lower( P<0.05,P<0.01);The level of IFN-γwas lower in the hight dose than in the model group(P<0.05);And renal pathological change was milder.Conclusion:qinghao-biejia group could inhibit the production of IL-6 and secretion of IFN-γand improve the pathologic lesion of lupus nephritis in MRL/lpr mice.