CAJ | 학술논문

HER2基因位于染色体17q12，与 HER1、HER3及 HER4组成了 EGFR（人类表皮生长因子受体）家族。HER2的同源或异质二聚体启动一系列的信号通路如：丝分裂原活化蛋白激酶（MAPK）、磷脂酰肌醇3－激酶（PI3K）、蛋白激酶 C（PKC）。通过这些通路影响着细胞的分化、增殖、血管生成和转移，并在许多癌症的发病机制中扮演着重要的角色。2007年的 ASCO 指导指出 HER2对于侵润性乳腺癌是一个很重要的预后、预测及治疗的标记。检测技术的标准化是评估 HER2状态准确性的关键。目前检测 HER2状态的方法有：IHC（免疫组织化学法）、FISH（荧光原位杂交）等。HER2过表达就会提示其预后较差，因此目前针对HER2治疗有多种靶向药物如：曲妥珠单抗、拉帕替尼、帕妥珠单抗及 Kadcyla（ado －曲妥珠单抗emtansine）等。
HER2기인위우염색체17q12，여 HER1、HER3급 HER4조성료 EGFR（인류표피생장인자수체）가족。HER2적동원혹이질이취체계동일계렬적신호통로여：사분렬원활화단백격매（MAPK）、린지선기순3－격매（PI3K）、단백격매 C（PKC）。통과저사통로영향착세포적분화、증식、혈관생성화전이，병재허다암증적발병궤제중분연착중요적각색。2007년적 ASCO 지도지출 HER2대우침윤성유선암시일개흔중요적예후、예측급치료적표기。검측기술적표준화시평고 HER2상태준학성적관건。목전검측 HER2상태적방법유：IHC（면역조직화학법）、FISH（형광원위잡교）등。HER2과표체취회제시기예후교차，인차목전침대HER2치료유다충파향약물여：곡타주단항、랍파체니、파타주단항급 Kadcyla（ado －곡타주단항emtansine）등。
HER2 gene located on chromosome 17q12,it formed EGFR(human epidermal growth factor receptor) family with HER1,HER3 and HER4.A series of signaling pathways were launched by homologous or heterodimer HER2,such as mitosis original activated protein kinase (MAPK),phosphatidyl inositol 3 kinase (PI3K),protein ki-nase C (PKC).Through these pathways HER2 affected cell differentiation,proliferation,angiogenesis and metastasis, and played an important role in the pathogenesis of cancer.The 2007 ASCO guidelines had pointed out that HER2 was an important marker in prognostic,prediction and treatment for invasion breast cancer.The key to accuracy assessment of HER2 status was the standardization of testing technology.Methods to detect HER2 status at present are the IHC (immune histochemical method)and FISH (fluorescence in situ hybridization)and so on.The overexpression of HER2 always followed a poor prognosis.In present there are a variety of targeted drugs for HER2 treatment such as Trastuzumab,Lapatinib,Pertuzumab and Kadcyla(ado -Trastuzumab emtansine).