CAJ | 학술논문

同源重组（HR）作为 DNA 双链断裂损伤的主要修复机制，其功能异常可影响肿瘤对放疗及基因毒药物的敏感性并可为肿瘤个体化治疗提供生物标志物。微小核糖核酸（microRNAs，miRNAs）通过与 mR-NA 的3＇端非编码区结合来实现对靶基因的转录后调控。近年来研究发现 miRNAs 对同源重组修复通路也发挥着重要的调控作用，并影响肿瘤对放疗及基因毒药物的敏感性。本文对肿瘤中 miRNAs 调控 HR 修复通路的新进展进行综述。
동원중조（HR）작위 DNA 쌍련단렬손상적주요수복궤제，기공능이상가영향종류대방료급기인독약물적민감성병가위종류개체화치료제공생물표지물。미소핵당핵산（microRNAs，miRNAs）통과여 mR-NA 적3＇단비편마구결합래실현대파기인적전록후조공。근년래연구발현 miRNAs 대동원중조수복통로야발휘착중요적조공작용，병영향종류대방료급기인독약물적민감성。본문대종류중 miRNAs 조공 HR 수복통로적신진전진행종술。
Homologous recombination (HR)served as the mainly repair pathway for DNA double strand breaks, which dysfunction could influence the sensitivity of radiotherapy and genotoxicity drugs.Presently,relevant clinical re-searches had confirmed the HR related gene or protein expression could be used as biomarkers for tumor individual-ized treatment.miRNAs (microRNAs)regulated the gene expression after transcription through combining the 3'un -translated region of mRNA.In recent years,the studies found that miRNAs played an important role in regulating HR repair pathway and also affected the tumor -sensitivity for radiotherapy and genotoxicity drugs.This review summari-zes the recent new progress of miRNAs in regulation for homologous recombination repair pathway on cancer.