CAJ | 학술논문

目的：评估小剂量奥氮平防治化疗所致恶心呕吐（CINV）的疗效。方法：80例需化疗患者随机分为两组，研究组（40例）和对照组（40例）。两组在化疗前给予静脉注射托烷司琼5mg，地塞米松5mg，研究组于化疗当天开始给予口服奥氮平5mg／d，观察两组化疗后恶心呕吐情况。结果：研究组和对照组急性呕吐发生率分别为22．5％（9／40）和47．5％（19／40），差异具有统计学意义（P ＜0．05），迟发型恶心呕吐的发生率分别为17．5％（7／40）和37．5（15／40），差异具有统计学意义（P ＜0．05）。结论：小剂量奥氮平（5mg／d）对防治化疗后恶心呕吐疗效明显。
목적：평고소제량오담평방치화료소치악심구토（CINV）적료효。방법：80례수화료환자수궤분위량조，연구조（40례）화대조조（40례）。량조재화료전급여정맥주사탁완사경5mg，지새미송5mg，연구조우화료당천개시급여구복오담평5mg／d，관찰량조화료후악심구토정황。결과：연구조화대조조급성구토발생솔분별위22．5％（9／40）화47．5％（19／40），차이구유통계학의의（P ＜0．05），지발형악심구토적발생솔분별위17．5％（7／40）화37．5（15／40），차이구유통계학의의（P ＜0．05）。결론：소제량오담평（5mg／d）대방치화료후악심구토료효명현。
Objective:To evaluate the curative effect of low -dose olanzapine in prevention and treatment of chemotherapy induced nausea and vomiting.Methods:80 cases of chemotherapy patients were randomly divided into two groups,the test group (40 cases),control group (40 cases).Before chemotherapy the test group and the control group given intravenously navoban tropisetron 5 mg and dexamethasone 5 mg,the test group were given olanzapine 5 mg daily started on the day of chemotherapy.Then two groups of nausea and vomiting after chemotherapy were ob-served.Results:The test group and the control group acute vomiting incidence was 22.5%(9 /40)and 47.5%(19 /40),with statistical significance (P <0.05),late onset incidence of nausea and vomiting were 17.5%(7 /40)and 37.5(15 /40),with statistical significance (P <0.05).Conclusion:Small dose of olanzapine (5mg/d)for preven-tion of nausea and vomiting after chemotherapy curative effect is obvious.