CAJ | 학술논문

目的：探讨胰岛素强化治疗方案对妊娠期糖尿病（ GDM）患者及胎儿的影响。方法：将70例妊娠期糖尿病患者按照随机数字表法分为2组，其中对照组35例用预混人胰岛素类进行常规治疗；观察组35例每天速效胰岛素3次注射加基础胰岛素1次注射进行强化治疗；对比分析两组患者治疗后血糖控制水平、胰岛素抵抗（ HOMA－IR）程度、胰岛素分泌指数（ HOMA－β）变化、妊娠合并症及新生儿合并症的发生率等。结果：观察组的患者血糖控制效果更佳，显著降低母婴并发症（ P＜0.01），胰岛素抵抗程度与胰岛素分泌功能均有所改善（ P＜0．05）。结论：胰岛素强化治疗妊娠期糖尿病可以减少母婴并发症的同时，可以在一定程度上改善患者的胰岛功能水平。
목적：탐토이도소강화치료방안대임신기당뇨병（ GDM）환자급태인적영향。방법：장70례임신기당뇨병환자안조수궤수자표법분위2조，기중대조조35례용예혼인이도소류진행상규치료；관찰조35례매천속효이도소3차주사가기출이도소1차주사진행강화치료；대비분석량조환자치료후혈당공제수평、이도소저항（ HOMA－IR）정도、이도소분비지수（ HOMA－β）변화、임신합병증급신생인합병증적발생솔등。결과：관찰조적환자혈당공제효과경가，현저강저모영병발증（ P＜0.01），이도소저항정도여이도소분비공능균유소개선（ P＜0．05）。결론：이도소강화치료임신기당뇨병가이감소모영병발증적동시，가이재일정정도상개선환자적이도공능수평。
Objective:To investigate the effect of intensive insulin therapy on patients with gestational diabetes mellitus ( GDM) .Meth-ods:70 cases of pregnancy with gestational diabetes were divided into 2 groups according to the random number table.The control group (n=35) pre mixed insulin class conventional therapy;observation group (35 cases) every available insulin three times injection plus basal insulin 1 injection intensive treatment;after treatment, the patients in the two groups compared with control of blood glucose levels, insulin resistance ( HOMA-IR) , insulin secretion index ( HOMA-β) changes, pregnancy complications and neonatal com-plications occurrence rate.Results:in the observation group, the patients blood glucose control effect is better, significantly reduce the complications of mothers and infants (P<0.01), the degree of insulin resistance and insulin secretion were somewhat improved (P<0.05) .Conclusion:insulin intensive treatment of gestational diabetes can reduce maternal and infant complications at the same time, to a certain extent, improve the level of pancreatic islet function.