CAJ | 학술논문

目的：了解该院流感嗜血杆菌临床分布特点及其耐药性，为临床医生合理利用抗菌药物提供依据。方法收集该院2012年全年流感嗜血杆菌共132株资料，利用WHONET5．6统计软件进行统计分析。结果在所收集的132株流感嗜血杆菌资料中，产β‐内酰胺酶64株，产酶率48．5％；耐药性分析显示：2012年全年该院临床分离出的132株H in对四环素耐药率最高，达81．1％，其次复方新诺明71．9％，氨苄西林48．5％，而对头孢曲松、亚胺培南、环丙沙星、阿奇霉素仍具有很好的敏感性，无1例耐药。结论头孢第2代、第3代、第2代喹诺酮类、大环内酯类、碳青霉烯类，可作为临床经验治疗的首选药；而四环素、磺胺类抑菌活性稍差（耐药率大于或接近50％），说明此类药物不适宜作为临床经验治疗。
목적：료해해원류감기혈간균림상분포특점급기내약성，위림상의생합리이용항균약물제공의거。방법수집해원2012년전년류감기혈간균공132주자료，이용WHONET5．6통계연건진행통계분석。결과재소수집적132주류감기혈간균자료중，산β‐내선알매64주，산매솔48．5％；내약성분석현시：2012년전년해원림상분리출적132주H in대사배소내약솔최고，체81．1％，기차복방신낙명71．9％，안변서림48．5％，이대두포곡송、아알배남、배병사성、아기매소잉구유흔호적민감성，무1례내약。결론두포제2대、제3대、제2대규낙동류、대배내지류、탄청매희류，가작위림상경험치료적수선약；이사배소、광알류억균활성초차（내약솔대우혹접근50％），설명차류약물불괄의작위림상경험치료。
Objective Understand the hospital clinical distribution characteristics and drug resistance of hae‐mophilus influenzae ,provide the basis for clinicians to reasonable use of antibiotics .Methods 132 strains of hae‐mophilus influenzae data were collected in 2012 ,the data were analysised by WHONET5 .6 statistical software .Re‐sults 64 strains of beta lactamase haemophilus influenzae was found in those 132 strains (48 .48% ) ,and Tetracy‐cline resistant rate is highest ,at 81 .06% ,followed by new Ming 71 .96% ,compound ampicillin 48 .48% ,and for ceftriaxone ,imine south ,ciprofloxacin and azithromycin still has the very good sensitivity ,no drug resistance in those strainsConclusion The second generation ,third -generation cephalosporin ,second generation quinolone ,large ring lactone class ,carbon penicillium alkene ,can be used as preferred drug for clinical treatment ;but the bacteriostatic of tetracycline ,and sulfa is a bit poor(the rate of resistance are greater than or close to 50% )it showed that such drugs is not suitable for clinical treatment .