CAJ | 학술논문

目的：提高对成人T细胞型急性淋巴细胞白血病诊断方法的认识方法报告1例特殊的成人 T细胞急性淋巴细胞白血病患者的临床资料、诊断过程、治疗、预后以及结合文献资料复习讨论。结果患者骨髓有核细胞增生明显，原始淋巴细胞占84％；CD7＋细胞95％，cCD3＋细胞占85％，CD38＋细胞占99．8％，CD2＋细胞占55．3％，CD34＋细胞占58．0％，CD1a＋细胞占47．9％，TdT＋细胞占43．5％，CD33＋阳性细胞占6．2％，cMPO＋细胞占1．5％；PAS染色阳性，POX染色存在阳性细胞，AS‐DAE染色少数阳性，α‐BE、α‐NAE、AS‐DCE染色均为阴性。给予患者急性淋巴细胞白血病标准诱导方案PVD方案（地塞米松，长春地辛，去甲氧柔红霉素）治疗1周期后缓解。结论诊断白血病时需结合临床症状，综合考虑形态学、免疫学、遗传学、分子生物学的检验结果得出诊断。
목적：제고대성인T세포형급성림파세포백혈병진단방법적인식방법보고1례특수적성인 T세포급성림파세포백혈병환자적림상자료、진단과정、치료、예후이급결합문헌자료복습토론。결과환자골수유핵세포증생명현，원시림파세포점84％；CD7＋세포95％，cCD3＋세포점85％，CD38＋세포점99．8％，CD2＋세포점55．3％，CD34＋세포점58．0％，CD1a＋세포점47．9％，TdT＋세포점43．5％，CD33＋양성세포점6．2％，cMPO＋세포점1．5％；PAS염색양성，POX염색존재양성세포，AS‐DAE염색소수양성，α‐BE、α‐NAE、AS‐DCE염색균위음성。급여환자급성림파세포백혈병표준유도방안PVD방안（지새미송，장춘지신，거갑양유홍매소）치료1주기후완해。결론진단백혈병시수결합림상증상，종합고필형태학、면역학、유전학、분자생물학적검험결과득출진단。
Objective To enhance the knowledge of diagnosis of adult T‐cell acute lymphocytic leukemia . Methods To report a special case of adult T‐cell acute lymphocytic leukemia ,including clinical features ,treatment and prognosis and the related literature was reviewed .Results Proliferation of bone marrow cells in patients with significant and the original lymphocyte cells was 84% .In bone marrow ,95% cells expressed CD7+ ,95% cCD3+85% ;CD38 ,99 .8% ;+ ;55 .3% CD2+ ;55 .3% CD34+ ;58 .0% ;CD1a+ 47 .9% TdT+43 .5 ;CD33+6 .2% ; ;cM‐PO+ ,1 .5% ;cMPO+ 1 .5% ..PAS staining was positive ,POX、α‐BE、α‐NAE、AS‐DCE staining was all negative . Given to patients with acute lymphoblastic leukemia standard induction regimen PVD program(dexamethasone ,vin‐desine ,idarubicin) ,after one cycle of treatment the patient was remission .Conclusion The diagnosis of T‐cell acute lymphoblastic leukemia requires a combination of clinical symptoms and the test results of morphology ,immunology , genetics ,molecular biology .