检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
z2期
35-37
,共3页
液基细胞%人乳头瘤病毒%筛查%宫颈病变
液基細胞%人乳頭瘤病毒%篩查%宮頸病變
액기세포%인유두류병독%사사%궁경병변
thinprep cytology test%human papillomavirus%screening%cervical lesion
目的：探讨宫颈液基细胞学（TCT）检查与人乳头瘤病毒（HPV）检测在宫颈病变筛查中的诊断作用，进一步提高TCT和HPV检测水平。方法对6514例已婚妇女采用TCT检查结合酶切信号放大技术进行14种高危HPV亚型感染检测，对细胞学（TBS）诊断大于或等于ASCUS及 HR‐HPV检测为阳性的妇女行阴道镜下宫颈组织活检，依据细胞异型性的程度和范围进行病理学分析。结果液基细胞学诊断大于或等于 ASCUS 为10．6％（690／6514），宫颈液基细胞学检查结果LSIL与组织病理学结果CINI级符合率63．5％（155／244），HSIL与CINⅡ级符合率69．6％（48／69）；HR‐HPV阳性检出率为19．6％（1276／6514），宫颈病变以高危型 HPV病毒 A9组常见，HPV16、HPV52亚型致癌性最强；HR‐HPV分型检测准确性高，持续感染是引起子宫颈癌的主要原因。结论液基细胞学检查结合人乳头瘤病毒的检测能有效提高宫颈病变的检出率，对宫颈癌前病变的早期诊断有重要价值。
目的：探討宮頸液基細胞學（TCT）檢查與人乳頭瘤病毒（HPV）檢測在宮頸病變篩查中的診斷作用，進一步提高TCT和HPV檢測水平。方法對6514例已婚婦女採用TCT檢查結閤酶切信號放大技術進行14種高危HPV亞型感染檢測，對細胞學（TBS）診斷大于或等于ASCUS及 HR‐HPV檢測為暘性的婦女行陰道鏡下宮頸組織活檢，依據細胞異型性的程度和範圍進行病理學分析。結果液基細胞學診斷大于或等于 ASCUS 為10．6％（690／6514），宮頸液基細胞學檢查結果LSIL與組織病理學結果CINI級符閤率63．5％（155／244），HSIL與CINⅡ級符閤率69．6％（48／69）；HR‐HPV暘性檢齣率為19．6％（1276／6514），宮頸病變以高危型 HPV病毒 A9組常見，HPV16、HPV52亞型緻癌性最彊；HR‐HPV分型檢測準確性高，持續感染是引起子宮頸癌的主要原因。結論液基細胞學檢查結閤人乳頭瘤病毒的檢測能有效提高宮頸病變的檢齣率，對宮頸癌前病變的早期診斷有重要價值。
목적：탐토궁경액기세포학（TCT）검사여인유두류병독（HPV）검측재궁경병변사사중적진단작용，진일보제고TCT화HPV검측수평。방법대6514례이혼부녀채용TCT검사결합매절신호방대기술진행14충고위HPV아형감염검측，대세포학（TBS）진단대우혹등우ASCUS급 HR‐HPV검측위양성적부녀행음도경하궁경조직활검，의거세포이형성적정도화범위진행병이학분석。결과액기세포학진단대우혹등우 ASCUS 위10．6％（690／6514），궁경액기세포학검사결과LSIL여조직병이학결과CINI급부합솔63．5％（155／244），HSIL여CINⅡ급부합솔69．6％（48／69）；HR‐HPV양성검출솔위19．6％（1276／6514），궁경병변이고위형 HPV병독 A9조상견，HPV16、HPV52아형치암성최강；HR‐HPV분형검측준학성고，지속감염시인기자궁경암적주요원인。결론액기세포학검사결합인유두류병독적검측능유효제고궁경병변적검출솔，대궁경암전병변적조기진단유중요개치。
Objective The purpose of the study is to explore the diagnostic value of Thinprep Cytologic Test (TCT)combined with human papillomavirus(HPV)detection in the cervical lesion screening and to improve the level of TCT and HPV testing .Methods A total of 6 514 married women were examined for 14 kinds of high‐risk HPV subtypes infection by using TCT test combined with enzyme cutting signal amplification technology .The colposcopy and cervical biopsy were taken in the women who were positive for HR‐ HPV testing and the Bethesda system (TBS)diagnosis ≥ASCUS .Then the pathology analysis was performed according to the degree and scope of cellular pleomorphism .Results Among the 6 514 cases ,the rate of TCT ≥ ASCUS was 10 .6% (690/6514) .The coninci‐dence rate of Low‐grade squamous intraepithelial lesions(HSIL)detected by Cervical TCT and Cervical intraepithelial neoplasia(CIN)identified by the histopathological test was up to 63 .5% (155/244) .The conincidence rate of HSIL and CINII was 69 .6% (48/69) .The positive rate of HR‐HPV testing was 19 .6(1 276/6 514) .High‐risk viruse A9 group is common in the cervical lesion .HPV16 and HPV52 subtype have the strongest carcinogenicity .Typing of HR‐HPV is accuracy .Persistent infection is the main cause of cervical cancer .Conclusion TCT combined with HPV detection can Improve the detection rate of cervical lesions .Which is important for the early diagnosis of cervical cancer lesion .
