药学与临床研究
藥學與臨床研究
약학여림상연구
PHARMACEUTICAL AND CLINICAL RESEARCH
2015年
4期
344-346
,共3页
李雪峰%徐振秋%刘俊超%王雪%刘莉莉%杨绪芳%萧伟
李雪峰%徐振鞦%劉俊超%王雪%劉莉莉%楊緒芳%蕭偉
리설봉%서진추%류준초%왕설%류리리%양서방%소위
聚酰胺树脂%银杏总内酯%纯化
聚酰胺樹脂%銀杏總內酯%純化
취선알수지%은행총내지%순화
Polyamide resin%Ginkgolides%Purification
目的：研究银杏总内酯的聚酰胺纯化工艺。方法：以树脂型号、上样量、洗脱溶剂、上样液浓度、柱径高比等为研究对象，进行工艺优化。结果：选择聚酰胺树脂，最佳上样提取物质量与柱体积比1∶50，洗脱溶剂为纯化水，径高比为1∶6，洗脱量2.5倍柱体积的纯化工艺，进行银杏总内酯纯化，其纯度达到70%以上。结论：纯化工艺操作简单，成本低廉，精制效果突出，有较高的工业生产应用价值。
目的：研究銀杏總內酯的聚酰胺純化工藝。方法：以樹脂型號、上樣量、洗脫溶劑、上樣液濃度、柱徑高比等為研究對象，進行工藝優化。結果：選擇聚酰胺樹脂，最佳上樣提取物質量與柱體積比1∶50，洗脫溶劑為純化水，徑高比為1∶6，洗脫量2.5倍柱體積的純化工藝，進行銀杏總內酯純化，其純度達到70%以上。結論：純化工藝操作簡單，成本低廉，精製效果突齣，有較高的工業生產應用價值。
목적：연구은행총내지적취선알순화공예。방법：이수지형호、상양량、세탈용제、상양액농도、주경고비등위연구대상，진행공예우화。결과：선택취선알수지，최가상양제취물질량여주체적비1∶50，세탈용제위순화수，경고비위1∶6，세탈량2.5배주체적적순화공예，진행은행총내지순화，기순도체도70%이상。결론：순화공예조작간단，성본저렴，정제효과돌출，유교고적공업생산응용개치。
Objective: To investigate the purification technology of ginkgolides from Ginkgo biloba L. Methods: With the content of ginkgolides as the index, resin type, sample volume and concentration, elu-tion solvent and the rate of column diameter to height were selected as technique parameters. Results: The optimum purification condition was as follows: polyamide resin, sample weight vs column volume 1∶50, col-umn diameter vs height 1∶6 and 2.5 times column volume of elution volume, then the purity of ginkgolides can reach more than 70%. Conclusion: Owing to simple operation, low cost and high purity, the above method for purification of ginkgolides can be widely used in practice.
