陕西医学杂志
陝西醫學雜誌
협서의학잡지
SHAANXI MEDICAL JOURNAL
2015年
8期
972-974
,共3页
肝硬化%胰岛素样生长因子-Ⅱ%胰岛素样生长因子结合蛋白-2
肝硬化%胰島素樣生長因子-Ⅱ%胰島素樣生長因子結閤蛋白-2
간경화%이도소양생장인자-Ⅱ%이도소양생장인자결합단백-2
liver cirrhosis%Insulin-Like growth factor%Insulin-Like growth factor-binding protein 2
目的：：探讨不同程度肝纤维化患者血清胰岛素样生长因子-2(IGF-2)及胰岛素样生长因子结合蛋白-2(IGFBP-2)与基质金属蛋白酶-2(MMPs)家族相关性。方法：选择到我院就诊的214例慢性乙肝患者,轻度组(A 组)、中度组(B 组)、重度组(C 组)及肝硬化组(D 组),分别有65、61、49、39例,对各组患者血清 IGF-2、IGFBP-2、MMP-2、TIMP-2进行检测。结果：Ⅱ组患者 IGF-2、IGFBP-2较Ⅰ组出现显著升高(P <0.05),Ⅲ组患者 IGF-2、IGFBP-2较Ⅰ组、Ⅱ组均出现显著升高(P <0.05),Ⅳ组患者 IGF-2、IGFBP-2较Ⅰ组、Ⅱ组、Ⅲ组均出现显著升高(P <0.05)。Ⅱ组患者 MMP-2/TIMP-2较Ⅰ组显著升高(P <0.05),Ⅲ组患者 MMP-2及 TIMP-2较Ⅰ组均出现显著差异(P <0.05),MMP-2/TIMP-2较Ⅰ组、Ⅱ组患者均出现显著升高(P <0.05),Ⅳ组患者 MMP-2及 TIMP-2及 MMP-2/TIMP-2较Ⅰ组、Ⅱ组、Ⅲ组均出现显著差异(P <0.05)。IGF-2与 TIMP-2、MMP-2/TIMP-2呈显著相关(P <0.05),IGFBP-2与 TIMP-2、MMP-2/TIMP-2呈显著相关(P<0.05)。结论：随着肝纤维化的进展,IGF-2及 IGFBP-2水平与细胞外基质重构密切相关,是反映肝纤维化进展的重要因子。
目的：：探討不同程度肝纖維化患者血清胰島素樣生長因子-2(IGF-2)及胰島素樣生長因子結閤蛋白-2(IGFBP-2)與基質金屬蛋白酶-2(MMPs)傢族相關性。方法：選擇到我院就診的214例慢性乙肝患者,輕度組(A 組)、中度組(B 組)、重度組(C 組)及肝硬化組(D 組),分彆有65、61、49、39例,對各組患者血清 IGF-2、IGFBP-2、MMP-2、TIMP-2進行檢測。結果：Ⅱ組患者 IGF-2、IGFBP-2較Ⅰ組齣現顯著升高(P <0.05),Ⅲ組患者 IGF-2、IGFBP-2較Ⅰ組、Ⅱ組均齣現顯著升高(P <0.05),Ⅳ組患者 IGF-2、IGFBP-2較Ⅰ組、Ⅱ組、Ⅲ組均齣現顯著升高(P <0.05)。Ⅱ組患者 MMP-2/TIMP-2較Ⅰ組顯著升高(P <0.05),Ⅲ組患者 MMP-2及 TIMP-2較Ⅰ組均齣現顯著差異(P <0.05),MMP-2/TIMP-2較Ⅰ組、Ⅱ組患者均齣現顯著升高(P <0.05),Ⅳ組患者 MMP-2及 TIMP-2及 MMP-2/TIMP-2較Ⅰ組、Ⅱ組、Ⅲ組均齣現顯著差異(P <0.05)。IGF-2與 TIMP-2、MMP-2/TIMP-2呈顯著相關(P <0.05),IGFBP-2與 TIMP-2、MMP-2/TIMP-2呈顯著相關(P<0.05)。結論：隨著肝纖維化的進展,IGF-2及 IGFBP-2水平與細胞外基質重構密切相關,是反映肝纖維化進展的重要因子。
목적：：탐토불동정도간섬유화환자혈청이도소양생장인자-2(IGF-2)급이도소양생장인자결합단백-2(IGFBP-2)여기질금속단백매-2(MMPs)가족상관성。방법：선택도아원취진적214례만성을간환자,경도조(A 조)、중도조(B 조)、중도조(C 조)급간경화조(D 조),분별유65、61、49、39례,대각조환자혈청 IGF-2、IGFBP-2、MMP-2、TIMP-2진행검측。결과：Ⅱ조환자 IGF-2、IGFBP-2교Ⅰ조출현현저승고(P <0.05),Ⅲ조환자 IGF-2、IGFBP-2교Ⅰ조、Ⅱ조균출현현저승고(P <0.05),Ⅳ조환자 IGF-2、IGFBP-2교Ⅰ조、Ⅱ조、Ⅲ조균출현현저승고(P <0.05)。Ⅱ조환자 MMP-2/TIMP-2교Ⅰ조현저승고(P <0.05),Ⅲ조환자 MMP-2급 TIMP-2교Ⅰ조균출현현저차이(P <0.05),MMP-2/TIMP-2교Ⅰ조、Ⅱ조환자균출현현저승고(P <0.05),Ⅳ조환자 MMP-2급 TIMP-2급 MMP-2/TIMP-2교Ⅰ조、Ⅱ조、Ⅲ조균출현현저차이(P <0.05)。IGF-2여 TIMP-2、MMP-2/TIMP-2정현저상관(P <0.05),IGFBP-2여 TIMP-2、MMP-2/TIMP-2정현저상관(P<0.05)。결론：수착간섬유화적진전,IGF-2급 IGFBP-2수평여세포외기질중구밀절상관,시반영간섬유화진전적중요인자。
Objective:To investigate the correlation analysis of IGF-2 and IGFBP-2 with MMPs in patients with liver fibrosis.Methods :214 cases of hepatitis B patients were divided into mild,moderate ,severe and cirrho-sis groups,there were 65、61、49、39 patients separately.Serum levels in patients of IGF-2,IGFBP -2,MMP-2, TIMP-2 were detected.Results:IGF-2,IGFBP-2 in patients with grade Ⅱ compared with Ⅰ appeared significantly higher level (P <0.05),IGF-2,IGFBP-2 of Ⅲ grade patients compared with gradeⅠ,Ⅱ grade were significantly higher (P <0.05),IGF-2,IGFBP-2 of Ⅳ grade compared with gradeⅠ,Ⅱgrade ,grade Ⅲ were significantly (P<0.05).MMP-2 /TIMP-2 in Ⅱ level patients compared with class Ⅰ was significantly higher (P <0.05),MMP-2 and TIMP-2 in Ⅲ grade patients compared with grade Ⅰ were any significant different(P < 0.05 ),MMP-2 /TIMP-2 compared with grade Ⅰ ,grade Ⅱ patients were significantly higher (P <0.05),MMP-2 and TIMP-2 and MMP-2 /TIMP-2 of Ⅳ grade compared with grade Ⅰ ,Ⅱ,Ⅲ were any significant different (P <0.05).IGF-2 and TIMP-2,MMP-2 / TIMP-2 were significantly correlated (P < 0.05 ),IGFBP-2 and TIMP-2,MMP-2 / TIMP-2 were significantly correlated (P <0.05).Conclusion :With the progress of liver fibrosis ,IGF-2 and IGFBP-2 levels are closely related to ECM remodelling ability ,which is an important factor to reflect the ability of liver fibrosis .
