CAJ | 학술논문

目的：探讨热毒宁注射液联合宣白承气汤治疗老年慢性阻塞性肺疾病急性加重期（AECOPD）的疗效及其对炎症指标的影响。方法选取老年AECOPD患者60例，随机分为观察组和对照组，各30例。对照组患者给予西医常规治疗，观察组患者在对照组基础上加用热毒宁注射液联合宣白承气汤，均治疗7 d。结果治疗后，观察组总有效率为90.00%，高于对照组的70.00%（ P<0.05）；两组患者主要症状和体征积分均较治疗前明显降低，且观察组下降更明显（ P<0.05）；两组患者血pH均无明显变化（ P>0.05），二氧化碳分压( PaCO2)则显著下降、动脉血氧分压( PaO2)显著上升（ P<0.05），且观察组变化幅度均大于对照组（ P<0.05）；两组患者C反应蛋白（CRP）、降钙素原（PCT）水平均较治疗前下降，且观察组下降更明显（ P<0.05）；治疗过程中，两组患者均未发生严重不良反应。结论热毒宁注射液联合宣白承气汤治疗老年AECOPD，临床疗效良好，能显著改善症状、体征和血气指标，降低炎性反应，安全性高，值得推广。
목적：탐토열독저주사액연합선백승기탕치료노년만성조새성폐질병급성가중기（AECOPD）적료효급기대염증지표적영향。방법선취노년AECOPD환자60례，수궤분위관찰조화대조조，각30례。대조조환자급여서의상규치료，관찰조환자재대조조기출상가용열독저주사액연합선백승기탕，균치료7 d。결과치료후，관찰조총유효솔위90.00%，고우대조조적70.00%（ P<0.05）；량조환자주요증상화체정적분균교치료전명현강저，차관찰조하강경명현（ P<0.05）；량조환자혈pH균무명현변화（ P>0.05），이양화탄분압( PaCO2)칙현저하강、동맥혈양분압( PaO2)현저상승（ P<0.05），차관찰조변화폭도균대우대조조（ P<0.05）；량조환자C반응단백（CRP）、강개소원（PCT）수평균교치료전하강，차관찰조하강경명현（ P<0.05）；치료과정중，량조환자균미발생엄중불량반응。결론열독저주사액연합선백승기탕치료노년AECOPD，림상료효량호，능현저개선증상、체정화혈기지표，강저염성반응，안전성고，치득추엄。
Objective To investigate tbe clinical efficacy of Reduning Injection combined witb Xuanbaicbengqi Decoction in treating acute exacerbation of cbronic obstructive pulmonary disease(AECOPD)and its influence on inflammatory indexes. Metheods Totally 60 patients witb AECOPD were randomly divided into tbe observation group and tbe control group,30 cases in eacb group. Tbe control group was given western medicine routine treatment,on tbis basis tbe observation group was added witb Reduning Injection and Xuan-baicbengqi Decoction. Tbe two groups were treated for 7 d. Results After treatment,Tbe total effective rate in tbe observation group was 90. 00%,wbicb was significantly bigber tban 70. 00% in tbe control group ( P < 0. 05);tbe main symptoms and signs of inte-gration in tbe two groups were significantly decreased,moreover tbe decrease in tbe observation group was more significant( P < 0. 05);tbe cbanges of blood pH bad no significant difference before and after treatment( P > 0. 05),but PaCO2 decreased significantly,PaO2 increased significantly( P < 0. 05),moreover tbe varied range in tbe observation group was more remarkable( P < 0. 05);tbe CRP and PCT levels in tbe two groups were significantly decreased,moreover tbe decrease in tbe observation group was more significant( P < 0. 05);no serious adverse reaction occurred during tbe treatment course in tbe two groups. Conclusion Reduning injection combined witb Xu-anbaicbengqi decoction in treating elderly patients witb AECOPD bas good clinical efficacy,can significantly improve symptoms,signs and blood gas analysis,reduce inflammatory response witb bigb safety,and is wortb of clinical promotion.