CAJ | 학술논문

目的：研究糖脉康颗粒对新诊断2型糖尿病患者的肠促胰岛素（GLP－1）与胰岛素抵抗的影响。方法选取医院收治的患者31例，均进行饮食、运动治疗，并给予糖脉康颗粒（口服，每次5 g，每日3次），每2周为1个疗程，治疗2个疗程。观察并记录患者治疗前后混合餐耐量试验（MMTT）情况，对各类症状进行分析评分；收集患者MMTT中0，15，30，60，90，120 min血标本，检验并记录血糖、GLP－1、胰岛素和C－肽变化情况；记录患者治疗前后血脂、血液流变学各项指标变化及不良反应发生情况。结果治疗后，患者临床症状评分明显降低（ P<0.05或 P<0.01）；GLP－1在60 min时增加（ P<0.05），其他时间段则无差异（ P>0.05），胰岛素、C－肽无明显变化（ P>0.05）；血糖在30，60，90，120 min明显降低（ P<0.05），且未出现低血糖，无其他不良反应。结论糖脉康颗粒可有效改善新诊断2型糖尿病患者的临床症状，改善胰岛素抵抗，提高胰岛素效率，对GLP－1无明显促进作用，安全性高，值得临床推广。
목적：연구당맥강과립대신진단2형당뇨병환자적장촉이도소（GLP－1）여이도소저항적영향。방법선취의원수치적환자31례，균진행음식、운동치료，병급여당맥강과립（구복，매차5 g，매일3차），매2주위1개료정，치료2개료정。관찰병기록환자치료전후혼합찬내량시험（MMTT）정황，대각류증상진행분석평분；수집환자MMTT중0，15，30，60，90，120 min혈표본，검험병기록혈당、GLP－1、이도소화C－태변화정황；기록환자치료전후혈지、혈액류변학각항지표변화급불량반응발생정황。결과치료후，환자림상증상평분명현강저（ P<0.05혹 P<0.01）；GLP－1재60 min시증가（ P<0.05），기타시간단칙무차이（ P>0.05），이도소、C－태무명현변화（ P>0.05）；혈당재30，60，90，120 min명현강저（ P<0.05），차미출현저혈당，무기타불량반응。결론당맥강과립가유효개선신진단2형당뇨병환자적림상증상，개선이도소저항，제고이도소효솔，대GLP－1무명현촉진작용，안전성고，치득림상추엄。
Objective To study tbe influence of Tangmaikang granule on GLP-1 and insulin resistance in newly diagnosed type 2 dia-betic patients. Methods Totally 31 patients were selected and treated by diet,exercise,and Tangmaikang granule(oral,5 g/time,3 times/d). Tbe course of treatment was two weeks,and tbe treatment lasted for two courses. To observe and record tbe MMTT of tbe pa-tients before and after tbe treatment,analyze and evaluate tbe symptoms scores. Tbe blood samples at 0,15,30,60,90,120 min during MMTT were collected,and tbe cbanges of blood glucose,insulin and C-peptide were examined and recorded. Tbe cbanges of blood lipids(TG,LDL-C,TC,HDL-C),bemorbeology and adverse reactions were recorded before and after treatment. Results Compared witb before treatment,tbe clinical symptom score was significantly lower( P < 0. 05 or P < 0. 01);GLP-1 increased at 60 min( P <0. 05),and tbere was no difference at otber time points( P > 0. 05);tbe insulin and C-peptides bad no significant cbange( P >0. 05);tbe glucose levels of blood glucose at 30,60,90,120 min were significantly decreased( P < 0. 05),and tbere were no bypo-glycemia and otber adverse reactions. Conclusion Tangmaikang can granule effectively improve tbe clinical symptoms of tbe newly diag-nosed type 2 diabetic patients,improve insulin resistance and tbe efficiency of insulin,bas no obvious promoting effect on GLP-1. It is safe and deserves to be clinically promoted.