中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
15期
85-86
,共2页
刘振霞%任菊香%张晋红%沙莎
劉振霞%任菊香%張晉紅%沙莎
류진하%임국향%장진홍%사사
肝硬化%腹腔积液%自发性细菌性腹膜炎%病原菌%耐药
肝硬化%腹腔積液%自髮性細菌性腹膜炎%病原菌%耐藥
간경화%복강적액%자발성세균성복막염%병원균%내약
cirrhosis%ascites%spontaneous bacterial peritonitis%pathogenic bacteria%drug resistance
目的：探讨肝硬化腹腔积液并自发性细菌性腹膜炎（SBP）患者的病原菌分布及其耐药率。方法对186例腹腔积液细菌培养阳性的肝硬化腹腔积液合并 SBP 患者的病原菌分布及药物敏感性检测结果进行回顾性分析。结果共检出致病菌208株，10个菌种。其中革兰阴性菌126株（60.58%），以大肠埃希菌62株（49.21%）、肺炎克雷伯杆菌32株（25.40%）为主；革兰阳性菌82株（39.42%），以金黄色葡萄球菌38株（46.34%）、表皮葡萄球菌22株（26.83%）为主。致病菌对亚胺培南、比阿培南、美洛培南的耐药率最低，其次是哌拉西林他唑巴坦、莫西沙星、阿米卡星；对环丙沙星、诺氟沙星、氧氟沙星、青霉素、头孢唑林、头孢呋辛有较高的耐药率。结论肝硬化腹腔积液并 SBP 的主要病原菌以革兰阴性菌为主，其中大肠埃希菌是最主要的致病菌，对头孢类及喹诺酮类抗菌药物的耐药性较高。
目的：探討肝硬化腹腔積液併自髮性細菌性腹膜炎（SBP）患者的病原菌分佈及其耐藥率。方法對186例腹腔積液細菌培養暘性的肝硬化腹腔積液閤併 SBP 患者的病原菌分佈及藥物敏感性檢測結果進行迴顧性分析。結果共檢齣緻病菌208株，10箇菌種。其中革蘭陰性菌126株（60.58%），以大腸埃希菌62株（49.21%）、肺炎剋雷伯桿菌32株（25.40%）為主；革蘭暘性菌82株（39.42%），以金黃色葡萄毬菌38株（46.34%）、錶皮葡萄毬菌22株（26.83%）為主。緻病菌對亞胺培南、比阿培南、美洛培南的耐藥率最低，其次是哌拉西林他唑巴坦、莫西沙星、阿米卡星；對環丙沙星、諾氟沙星、氧氟沙星、青黴素、頭孢唑林、頭孢呋辛有較高的耐藥率。結論肝硬化腹腔積液併 SBP 的主要病原菌以革蘭陰性菌為主，其中大腸埃希菌是最主要的緻病菌，對頭孢類及喹諾酮類抗菌藥物的耐藥性較高。
목적：탐토간경화복강적액병자발성세균성복막염（SBP）환자적병원균분포급기내약솔。방법대186례복강적액세균배양양성적간경화복강적액합병 SBP 환자적병원균분포급약물민감성검측결과진행회고성분석。결과공검출치병균208주，10개균충。기중혁란음성균126주（60.58%），이대장애희균62주（49.21%）、폐염극뢰백간균32주（25.40%）위주；혁란양성균82주（39.42%），이금황색포도구균38주（46.34%）、표피포도구균22주（26.83%）위주。치병균대아알배남、비아배남、미락배남적내약솔최저，기차시고랍서림타서파탄、막서사성、아미잡성；대배병사성、낙불사성、양불사성、청매소、두포서림、두포부신유교고적내약솔。결론간경화복강적액병 SBP 적주요병원균이혁란음성균위주，기중대장애희균시최주요적치병균，대두포류급규낙동류항균약물적내약성교고。
Objective To explore the pathogenic bacteria and their drug resistance for patients with cirrhosis and ascites complicated with spontaneous bacterial peritonitis and provide references for clinical reas - onable using antibiotics. Methods The pathogenic bacteria and their drug resistance of 186 patients with cirrhosis and ascites complicated with spontaneous bacterial peritonitis were retrospectively analyzed. Results There were total of 208 bacteria strains and 10 kinds of bacteria were detected. The number of strains for G - bacil-lus was 126 (60. 58% ), and mainly in Escherichia coli (62 strains, 49. 21% ) and Klebsiella pneumoniae (32 strains, 25. 40% ) . There were 82 strains of G + bacillus(39. 42% ) and mainly in Staphylococcus aureus (38 strains, 46. 34% ) and Staphylococcus epidermidis (22 strains, 26. 83% ) . The drug resistance rate to Imipenem, Biapenem and Meropenem was lowest followed with Piperacillin / Tazobac-tam, Moxifloxacin and Amikacin. The drug resistance rate to Ciprofloxacin, Norfloxacin, Ofloxacin, penicillin, Cefazolin and Cefuroxime was higher. Conclusion The main pathogenic bacteria for patients with cirrhosis and ascites complicated with spontaneous bacterial peritoni-tis was G - bacillus mainly in Escherichia coli and has higher resistance to cephalosporin Quinolones antibiotics.
