中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
16期
67-68,69
,共3页
右美托咪定%可视喉镜%全身麻醉%气管插管
右美託咪定%可視喉鏡%全身痳醉%氣管插管
우미탁미정%가시후경%전신마취%기관삽관
dexmedetomidine%UE-HC glidescope%general anestbesia endotracbeal intubation
目的：观察右美托咪定联合UE－HC可视喉镜用于全身麻醉（简称全麻）气管插管老年患者的临床疗效。方法选择医院2013年收治的行全麻气管插管治疗老年患者126例，按随机数字表法分为观察组和对照组，各63例。气管插管前，观察组静脉注射右美托咪定，对照组静脉注射等量0.9%氯化钠注射液，观察两组患者在进入手术室平静后（T0），麻醉诱导时（T1），气管插管时（T2）、插管后3 min（T3）、拔管时（T4）、拔管后3 min（T5）时心率（HR）、舒张压（DBP）及收缩压（SBP）等指标的变化。结果观察组患者的HR及DBP， SBP在T1及以后的各个时间点均显著低于对照组（ P<0.05）；观察组呛咳、躁动、恶心等不良反应显著少于对照组（ P<0.05）；观察组患者在气管插管过程中未出现呼吸抑制症状，拔管后安静入睡率为63.49%，显著高于对照组的19.05%（ P<0.05）。结论右美托咪定结合UE－HC可视喉镜用于全麻气管插管老年患者，可有效避免心动过速，提高血流动力学稳定性，无呼吸抑制，镇静效果显著，且可减少呛咳等不良反应的发生率，值得临床推广。
目的：觀察右美託咪定聯閤UE－HC可視喉鏡用于全身痳醉（簡稱全痳）氣管插管老年患者的臨床療效。方法選擇醫院2013年收治的行全痳氣管插管治療老年患者126例，按隨機數字錶法分為觀察組和對照組，各63例。氣管插管前，觀察組靜脈註射右美託咪定，對照組靜脈註射等量0.9%氯化鈉註射液，觀察兩組患者在進入手術室平靜後（T0），痳醉誘導時（T1），氣管插管時（T2）、插管後3 min（T3）、拔管時（T4）、拔管後3 min（T5）時心率（HR）、舒張壓（DBP）及收縮壓（SBP）等指標的變化。結果觀察組患者的HR及DBP， SBP在T1及以後的各箇時間點均顯著低于對照組（ P<0.05）；觀察組嗆咳、躁動、噁心等不良反應顯著少于對照組（ P<0.05）；觀察組患者在氣管插管過程中未齣現呼吸抑製癥狀，拔管後安靜入睡率為63.49%，顯著高于對照組的19.05%（ P<0.05）。結論右美託咪定結閤UE－HC可視喉鏡用于全痳氣管插管老年患者，可有效避免心動過速，提高血流動力學穩定性，無呼吸抑製，鎮靜效果顯著，且可減少嗆咳等不良反應的髮生率，值得臨床推廣。
목적：관찰우미탁미정연합UE－HC가시후경용우전신마취（간칭전마）기관삽관노년환자적림상료효。방법선택의원2013년수치적행전마기관삽관치료노년환자126례，안수궤수자표법분위관찰조화대조조，각63례。기관삽관전，관찰조정맥주사우미탁미정，대조조정맥주사등량0.9%록화납주사액，관찰량조환자재진입수술실평정후（T0），마취유도시（T1），기관삽관시（T2）、삽관후3 min（T3）、발관시（T4）、발관후3 min（T5）시심솔（HR）、서장압（DBP）급수축압（SBP）등지표적변화。결과관찰조환자적HR급DBP， SBP재T1급이후적각개시간점균현저저우대조조（ P<0.05）；관찰조창해、조동、악심등불량반응현저소우대조조（ P<0.05）；관찰조환자재기관삽관과정중미출현호흡억제증상，발관후안정입수솔위63.49%，현저고우대조조적19.05%（ P<0.05）。결론우미탁미정결합UE－HC가시후경용우전마기관삽관노년환자，가유효피면심동과속，제고혈류동역학은정성，무호흡억제，진정효과현저，차가감소창해등불량반응적발생솔，치득림상추엄。
Objective To observe tbe clinical effect of dexmedetomidine combined witb UE-HC glidescope in elderly patients witb gen-eral anestbesia endotracbeal intubation. Methods 126 patients witb general anestbesia endotracbeal intubation in tbe bospital during 2013 were selected and randomly divided into tbe observation group and tbe control group according to tbe random number table,63 cases in eacb group. Tbe observation group was intravenously injected by dexmedetomidine before endotracbeal intubation,wbile tbe con-trol group was intravenously injected by tbe same amount of 0. 9% sodium cbloride injection before endotracbeal intubation. Tbe cbanges of HR,DBP,SBP at calmness after entering operation room(T0),anestbesia induction(T1),endotracbeal intubation(T2),at 3 min after en-dotracbeal intubation(T3),extubation(T4) and at 3 min after extubation(T5) were observed in tbe two groups. Results HR,DBP and SBP at various time points after anestbesia induction(T1) in tbe observation group were significantly lower tban tbose in tbe control group( P < 0. 05). Tbe adverse reactions of bucking,restlessness and nausea occurred in tbe observation group were significantly less tban tbose in tbe control group( P < 0. 05);tbe observation group bad no respiratory depression symptoms in tbe course of intubation, tbe quiet sleep rate after extubation in tbe observation group was 63. 49%,wbicb was significantly bigber tban 19. 05% in tbe control group( P < 0. 05). Conclusion Tbe application of dexmedetomidine combined witb UE-HC glidescope in elderly patients witb general anestbesia endotracbeal intubation can effectively avoid tacbycardia,improve tbe bemodynamic stability,bas no respiratory depression witb significantly sedative effect,can reduce tbe incidence of adverse reactions sucb as bucking,wbicb is wortby of clinical promotion.
