中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
16期
41-42,43
,共3页
地佐辛%结肠癌手术%硬膜外%静脉自控镇痛
地佐辛%結腸癌手術%硬膜外%靜脈自控鎮痛
지좌신%결장암수술%경막외%정맥자공진통
dezocine%colon cancer operation%epidural%intravenous self-control analgesia
目的：探讨地佐辛用于结肠癌患者术后镇痛的路径，对比不同给药方式的临床镇痛效果及安全性。方法选取2013年6月至2014年5月医院外科收治的结肠癌手术患者84例，随机分为观察组与对照组，各42例。观察组患者采用硬膜外一次性给予经10 mL 0.9%氯化钠注射液稀释的地佐辛5 mg，接静脉自控镇痛泵（地佐辛10 mg／kg，托烷司琼5 mg／kg，氟比洛芬酯注射液100 mg／kg，0.9%氯化钠注射液稀释为100 mL）镇痛。对照组患者术毕给予静脉注射地佐辛5 mg／kg，接相同自控镇痛泵镇痛。观察两组患者术后48 b的疼痛视觉模拟( VAS )评分、镇痛满意率、不良反应发生率。结果观察组患者术后镇痛效果及镇痛满意度均明显优于对照组（ P<0.05）。结论地佐辛硬膜外一次性给药联合静脉自控镇痛，能有效改善结肠癌患者术后疼痛情况，镇痛效果较好，为结肠癌术后较理想的镇痛方法。
目的：探討地佐辛用于結腸癌患者術後鎮痛的路徑，對比不同給藥方式的臨床鎮痛效果及安全性。方法選取2013年6月至2014年5月醫院外科收治的結腸癌手術患者84例，隨機分為觀察組與對照組，各42例。觀察組患者採用硬膜外一次性給予經10 mL 0.9%氯化鈉註射液稀釋的地佐辛5 mg，接靜脈自控鎮痛泵（地佐辛10 mg／kg，託烷司瓊5 mg／kg，氟比洛芬酯註射液100 mg／kg，0.9%氯化鈉註射液稀釋為100 mL）鎮痛。對照組患者術畢給予靜脈註射地佐辛5 mg／kg，接相同自控鎮痛泵鎮痛。觀察兩組患者術後48 b的疼痛視覺模擬( VAS )評分、鎮痛滿意率、不良反應髮生率。結果觀察組患者術後鎮痛效果及鎮痛滿意度均明顯優于對照組（ P<0.05）。結論地佐辛硬膜外一次性給藥聯閤靜脈自控鎮痛，能有效改善結腸癌患者術後疼痛情況，鎮痛效果較好，為結腸癌術後較理想的鎮痛方法。
목적：탐토지좌신용우결장암환자술후진통적로경，대비불동급약방식적림상진통효과급안전성。방법선취2013년6월지2014년5월의원외과수치적결장암수술환자84례，수궤분위관찰조여대조조，각42례。관찰조환자채용경막외일차성급여경10 mL 0.9%록화납주사액희석적지좌신5 mg，접정맥자공진통빙（지좌신10 mg／kg，탁완사경5 mg／kg，불비락분지주사액100 mg／kg，0.9%록화납주사액희석위100 mL）진통。대조조환자술필급여정맥주사지좌신5 mg／kg，접상동자공진통빙진통。관찰량조환자술후48 b적동통시각모의( VAS )평분、진통만의솔、불량반응발생솔。결과관찰조환자술후진통효과급진통만의도균명현우우대조조（ P<0.05）。결론지좌신경막외일차성급약연합정맥자공진통，능유효개선결장암환자술후동통정황，진통효과교호，위결장암술후교이상적진통방법。
Objective To investigate tbe route of dezocine used for postoperative analgesia in patients witb colon cancer and to contrast tbe clinical analgesic effects and safety among different administration modes. Methods 84 patients witb colon cancer operation in tbe surgical department of tbe bospital from June 2013 to May 2014 were selected and randomly divided into tbe observation group and tbe control group,42 cases in eacb group. Tbe observation group was given dezocine 5 mg diluted witb 0. 9% sodium cbloride injection 10 mL by once epidural injection and connected witb tbe self-control analgesic pump(dezocine 10 mg/kg,tropisetron 5 mg/kg,flur-biprofen axetil injection 100 mg/kg,0. 9% sodium cbloride injection diluted to 100 mL) for conducting analgesia. Tbe control group was intravenously injected dezocine 5 mg/kg and connected tbe self-control analgesic pump for conducting analgesia. Tbe VAS score, analgesic satisfaction rate and tbe occurrence rate of adverse reactions witbin postoperative 48 b were observed in tbe two groups. Results Tbe postoperative analgesic effect and analgesic satisfaction in tbe observation group were significantly better tban tbose in tbe control group( P < 0. 05). Conclusion Dezocine by once epidural injection combined witb intravenous self-control analgesia can effectively improve postoperative pain in tbe patients witb colon cancer,bas good analgesic effect,and is a more ideal analgesic metbod after colon cancer operation.
