CAJ | 학술논문

目的：研究壮药白花九里明提取物的急性毒性和体内抗菌的作用。方法序贯法测定壮药白花九里明水、醇提物对小鼠的急性毒性；感染动物保护实验测定壮药白花九里明不同剂量水提物对金黄色葡萄球菌、肺炎克雷伯菌感染的小鼠体内保护作用。结果壮药白花九里明水提取物小鼠灌胃的LD50为（134．17±9．043） g生药／kg，95％的可信限为（125．127，143．213）；醇提取物 LD50为（107．37±17．665） g 生药／kg，95％的可信限为（89．705，125．035）。壮药白花九里明水提物6．7 g／kg、13．4 g／kg、26．8 g／kg均能不同程度地降低金黄色葡萄球菌感染小鼠的病死率并延长平均存活时间。结论壮药白花九里明提取物为低毒，大剂量服用比较安全；对金黄色葡萄球菌感染的小鼠有一定的体内保护作用，值得进一步研究与开发。
목적：연구장약백화구리명제취물적급성독성화체내항균적작용。방법서관법측정장약백화구리명수、순제물대소서적급성독성；감염동물보호실험측정장약백화구리명불동제량수제물대금황색포도구균、폐염극뢰백균감염적소서체내보호작용。결과장약백화구리명수제취물소서관위적LD50위（134．17±9．043） g생약／kg，95％적가신한위（125．127，143．213）；순제취물 LD50위（107．37±17．665） g 생약／kg，95％적가신한위（89．705，125．035）。장약백화구리명수제물6．7 g／kg、13．4 g／kg、26．8 g／kg균능불동정도지강저금황색포도구균감염소서적병사솔병연장평균존활시간。결론장약백화구리명제취물위저독，대제량복용비교안전；대금황색포도구균감염적소서유일정적체내보호작용，치득진일보연구여개발。
Objective It is to study the acute toxicity and bacteriostasis in vitro of extracts from the Blumea megacephala (Randeria) chamg et Tseng.Methods Sequential method was used to determine the acute toxicity of aqueous extract and alco -hol extract of Blumea megacephala ( Randeria ) chamg et Tseng in mice .Infected animal protecting experiment was used to de-termine the extract on staphylococcus aureus , klebsiella pneumoniae infection in mice .Result The LD50 and 95%confidence interval of aqueous extract and alcohol extract to the Mice IG were 134 .17 ±9 .043 g, 125 .127-143 .213 g raw material/kg and 107.37 ±17.665g raw material/kg, 89.705-125.035g raw material/kg respectively.High(26.8 g/kg), medium(13. 4g/kg),low (6.7g/kg)dose group of of the aqueous extract of Blumea megacephala (Randeria)chang et Tseng could all de -press the death rate leng then the average survival time of mice in fected by Staphylococcus aureus .Conclusion The aqueous extract and alcohol extract of Blumea megacephala (Randeria) chamg et Tseng is low toxicity.high doses of the aqueous ex-tract of Blumea megacephala ( Randeria) chamg et Tseng have remarkable protecting effect on mice infected by Staphylococcus aureus , so it deserves further research and development .