CAJ | 학술논문

目的：探讨FRAX评分评估初诊2型糖尿病患者10年骨质疏松骨折发生概率的价值。方法选取207例初发糖尿病患者作为糖尿病组，健康体检者504例作为对照组，收集2组相关临床指标，同时采用双能X射线骨密度仪检查腰椎L1—4、左侧股骨颈及Ward＇s三角的骨密度，并按照总体、男性、女性分别通过FRAX公式计算2组10年髋部骨折发生概率和10年主要骨质疏松性骨折发生概率，比较2组不同年龄段骨量情况及10年骨折发生概率。结果糖尿病组中总体、男性以及女性既往骨折发病率均明显高于对照组（P 均＜0．05），糖尿病组股骨颈及L1的骨密度值均高于对照组（P均＜0．05）；糖尿病组10年主要骨质疏松性骨折发生概率和10年髋部骨折发生概率均低于对照组（ P均＜0．05）。随着年龄段的增长，2组骨量减少的发生率及10年骨折发生概率均呈逐渐上升趋势（P均＜0．05），而2组相同年龄段骨量减少发生率比较差异均无统计学意义（ P均＞0．05）；糖尿病组＞50～60岁、＞60～70岁、＞70岁人群10年髋部骨折发生概率和10年主要骨质疏松性骨折发生概率均明显低于对照组（P均＜0．05）。结论随着年龄段的增长，2型糖尿病患者10年骨折发生概率逐渐增高。在2型糖尿病患者中，应当建立更加精准的FRAX评分工具来预测糖尿病患者骨折风险。
목적：탐토FRAX평분평고초진2형당뇨병환자10년골질소송골절발생개솔적개치。방법선취207례초발당뇨병환자작위당뇨병조，건강체검자504례작위대조조，수집2조상관림상지표，동시채용쌍능X사선골밀도의검사요추L1—4、좌측고골경급Ward＇s삼각적골밀도，병안조총체、남성、녀성분별통과FRAX공식계산2조10년관부골절발생개솔화10년주요골질소송성골절발생개솔，비교2조불동년령단골량정황급10년골절발생개솔。결과당뇨병조중총체、남성이급녀성기왕골절발병솔균명현고우대조조（P 균＜0．05），당뇨병조고골경급L1적골밀도치균고우대조조（P균＜0．05）；당뇨병조10년주요골질소송성골절발생개솔화10년관부골절발생개솔균저우대조조（ P균＜0．05）。수착년령단적증장，2조골량감소적발생솔급10년골절발생개솔균정축점상승추세（P균＜0．05），이2조상동년령단골량감소발생솔비교차이균무통계학의의（ P균＞0．05）；당뇨병조＞50～60세、＞60～70세、＞70세인군10년관부골절발생개솔화10년주요골질소송성골절발생개솔균명현저우대조조（P균＜0．05）。결론수착년령단적증장，2형당뇨병환자10년골절발생개솔축점증고。재2형당뇨병환자중，응당건립경가정준적FRAX평분공구래예측당뇨병환자골절풍험。
Objective It is to explore the value of FRAX score for evaluating fracture risk induced by osteoporosis in new-diagnostic type 2 diabetes patients in ten years .Methods These 207 subjects with new-diagnosed diabetes were selected as DM group and 504 healthy subjects as normal -control ( NC group) were enrolled and were collected and their clinical infor-mation were collected .The bone mineral density of lumbar vertebra L 1-4, left femoral neck and Ward's triangle was meas-ured by dual -energy X-ray absorptiometry examination.The 10-year probability of hip fracture(PHF) and a major osteopo-rotic fracture(PMOF) was calculated by FRAX algorithm according to totality , male and female.The bone mineral density of different age group and 10-year probability of fracture between the two groups were compared .Results In the total , male and female subjects the frequency of previous fracture in DM group was higher than that in NC group (P<0.05).The T value at femur neck and lumbar spine L1 in DM group were higher than NC group(P<0.05).The 10-year probability of PHF and a major PMOF in DM group was lower than that in NC group (P<0.05).With age increasing, occurrence rate of bone mineral density decreasing and 10-year probability of fracture increased gradually (P<0.05) in both groups, but there was no sig-nificant difference in occurrence rate of bone mineral density decreasing among the groups with same age in both groups ( P>0.05).In DM group, the 10-year probability of PHF and a major PMOF of the ones whose age >50-60, >60-70, >70 years were obviously lower than that of NC group (P<0.05).Conclusion The 10-year probability osteoporotic fracture had an increased trend with the increasing age .In type 2 diabetes,we should set up more precise algorithm model to predict frac-ture risk of diabetes .