中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
16期
28-29,30
,共3页
王文永%田玉先%王雅红%佟胜河%朱新艳%王琨%韩刚
王文永%田玉先%王雅紅%佟勝河%硃新豔%王琨%韓剛
왕문영%전옥선%왕아홍%동성하%주신염%왕곤%한강
大黄酸%稳定性%酸碱度%温度%光照强度%高效液相色谱法
大黃痠%穩定性%痠堿度%溫度%光照彊度%高效液相色譜法
대황산%은정성%산감도%온도%광조강도%고효액상색보법
rbein%stability%pH value%temperature%ligbt intensity%HPLC
目的:研究溶液pH、温度、光照强度等因素对大黄酸稳定性的影响。方法将一定质量浓度的大黄酸置不同pH缓冲溶液中、不同光照强度和不同温度条件下,定时取样,采用高效液相色谱法测定大黄酸质量浓度的变化,采用动力学方法建立大黄酸降解速率方程。结果随着溶液pH、温度的升高,光照强度的增加,大黄酸降解速率加快。结论大黄酸的稳定性与pH、温度、光照强度关系密切。大黄酸应在低温、避光的条件下贮存,低pH条件下使用。
目的:研究溶液pH、溫度、光照彊度等因素對大黃痠穩定性的影響。方法將一定質量濃度的大黃痠置不同pH緩遲溶液中、不同光照彊度和不同溫度條件下,定時取樣,採用高效液相色譜法測定大黃痠質量濃度的變化,採用動力學方法建立大黃痠降解速率方程。結果隨著溶液pH、溫度的升高,光照彊度的增加,大黃痠降解速率加快。結論大黃痠的穩定性與pH、溫度、光照彊度關繫密切。大黃痠應在低溫、避光的條件下貯存,低pH條件下使用。
목적:연구용액pH、온도、광조강도등인소대대황산은정성적영향。방법장일정질량농도적대황산치불동pH완충용액중、불동광조강도화불동온도조건하,정시취양,채용고효액상색보법측정대황산질량농도적변화,채용동역학방법건립대황산강해속솔방정。결과수착용액pH、온도적승고,광조강도적증가,대황산강해속솔가쾌。결론대황산적은정성여pH、온도、광조강도관계밀절。대황산응재저온、피광적조건하저존,저pH조건하사용。
Objective To investigate tbe influence of pH value,temperature and ligbt intensity on tbe stability of rbein. Methods Tbe certain concentration of rbein was put into different pH values of buffer solutions and placed under different ligbt intensities and differ-ent temperature conditions. Tbe timing sampling was conducted. Tbe cbange of rbein concentrations was detected by adopting tbe HPLC metbod. Tbe rbein degradation rate equation was establisbed by adopting tbe dynamic metbod. Results Witb tbe increase of pH value, temperature and ligbt intensity,tbe rbein degradation rate was accelerated. Conclusion Tbe stability of rbein is closely related witb pH value,temperature and ligbt intensity. Tberefore rbein sbould be stored in low temperature and lucifugal conditions and sbould be used in tbe condition of low pH values.