CAJ | 학술논문

目的：调查分析川东北地区某二甲医院超药品说明书用药的情况，为促进皮肤科合理用药提供基线数据。方法随机抽取2013年门诊皮肤科处方2400张，含6137条用药记录。根据药品说明书内容，判断是否超说明书用药，并分析超说明书用药的类型。结果超说明书用药处方423张，占17.62%；超说明书用药记录1152条，占18.77%。超说明书用药类型中居前3位的为超适应证（38.30%）、改变给药途径（26.71%）、超剂量（19.39%）。结论皮肤科门诊处方中超药品说明书用药情况普遍，应严格按照药品说明书规定的适应证、用法用量，选择适宜患者的药物剂型，以减少超说明书用药，提高用药安全性。
목적：조사분석천동북지구모이갑의원초약품설명서용약적정황，위촉진피부과합리용약제공기선수거。방법수궤추취2013년문진피부과처방2400장，함6137조용약기록。근거약품설명서내용，판단시부초설명서용약，병분석초설명서용약적류형。결과초설명서용약처방423장，점17.62%；초설명서용약기록1152조，점18.77%。초설명서용약류형중거전3위적위초괄응증（38.30%）、개변급약도경（26.71%）、초제량（19.39%）。결론피부과문진처방중초약품설명서용약정황보편，응엄격안조약품설명서규정적괄응증、용법용량，선택괄의환자적약물제형，이감소초설명서용약，제고용약안전성。
Objective To investigate the off - label drug use in outpatient department of dermatology in a Level 2A hospital of Northeast Sichuan, and to provide reference for promoting the rational drug use. Methods Author sampled 2 400 prescriptions in total, all sample prescriptions of it contained 6 137 records, randomly sampled the prescriptions in outpatient department of dermatology in 2013, and ac-cording to these relevant information based on drug instructions, to estimate whether it belongs to the off - label drug use, and the off -label used was determined according to the package inserts in the following aspects, the types of off - label use. Results There were 423(17. 62% ) off - label drug use prescriptions, involved 1 152 records(18. 77% ) about off - label use. Among them 38. 30% prescrip-tions were exceed indications, 26. 71% prescriptions were changed the route of administration, 19. 39% prescriptions were exceed the pre-scribed dose. Conclusion The situation of off - label drug use in department of dermatology is very common. It is an effective approach to reduce off - label use and improve drug safety through strictly abiding by the instruction of usage and dosage as well as selecting a suitable dosage form.