中国医学装备
中國醫學裝備
중국의학장비
CHINA MEDICAL EQUIPMENT
2015年
8期
4-6,7
,共4页
同型半胱氨酸%超敏C反应蛋白%超声诊断%缺血性脑卒中
同型半胱氨痠%超敏C反應蛋白%超聲診斷%缺血性腦卒中
동형반광안산%초민C반응단백%초성진단%결혈성뇌졸중
Homocysteine%High sensitivity C reactive protein%Ischemic stroke
目的：探讨彩色多普勒超声结合同型半胱氨酸(Hcy)、超敏C反应蛋白(Hs-CRP)在缺血性脑卒中预后中的诊断意义。方法：选择200例缺血性脑卒中患者，依据临床表现和诊断结果将其分为非进展性脑卒中组(110例)和进展性脑卒中组(90例)。采用彩色多普勒超声诊断仪测量所有患者的颈总动脉内膜中层厚度，并对两组患者的颈总动脉内膜中层厚度以及入院及治疗两周后的Hcy与Hs-CRP的水平进行比较。结果：经彩色多普勒超声检查显示，进展性脑卒中患者颈内动脉血管粥样斑块形成，血管内膜厚度增加，血管腔变狭窄。进展性脑卒中组的平均颈总动脉内膜中层厚度为(1.54±0.39)mm，显著高于非进展性脑卒中组(1.08±0.23)mm，差异有统计学意义(t=10.37，P＜0.05)；进展性脑卒中组入院时及治疗2周后的Hcy水平显著高于非进展性脑卒中组，差异有统计学意义(t=5.104，P＜0.05)；进展性脑卒中组入院时及治疗2周后的Hs-CRP水平亦显著高于非进展性脑卒中组，差异有统计学意义(t=7.552，P＜0.05)。结论：血清中的Hcy和Hs-CRP水平可作为评估缺血性脑卒中预后的重要指标，结合彩色多普勒超声诊断其结果更为精确，值得临床推广。
目的：探討綵色多普勒超聲結閤同型半胱氨痠(Hcy)、超敏C反應蛋白(Hs-CRP)在缺血性腦卒中預後中的診斷意義。方法：選擇200例缺血性腦卒中患者，依據臨床錶現和診斷結果將其分為非進展性腦卒中組(110例)和進展性腦卒中組(90例)。採用綵色多普勒超聲診斷儀測量所有患者的頸總動脈內膜中層厚度，併對兩組患者的頸總動脈內膜中層厚度以及入院及治療兩週後的Hcy與Hs-CRP的水平進行比較。結果：經綵色多普勒超聲檢查顯示，進展性腦卒中患者頸內動脈血管粥樣斑塊形成，血管內膜厚度增加，血管腔變狹窄。進展性腦卒中組的平均頸總動脈內膜中層厚度為(1.54±0.39)mm，顯著高于非進展性腦卒中組(1.08±0.23)mm，差異有統計學意義(t=10.37，P＜0.05)；進展性腦卒中組入院時及治療2週後的Hcy水平顯著高于非進展性腦卒中組，差異有統計學意義(t=5.104，P＜0.05)；進展性腦卒中組入院時及治療2週後的Hs-CRP水平亦顯著高于非進展性腦卒中組，差異有統計學意義(t=7.552，P＜0.05)。結論：血清中的Hcy和Hs-CRP水平可作為評估缺血性腦卒中預後的重要指標，結閤綵色多普勒超聲診斷其結果更為精確，值得臨床推廣。
목적：탐토채색다보륵초성결합동형반광안산(Hcy)、초민C반응단백(Hs-CRP)재결혈성뇌졸중예후중적진단의의。방법：선택200례결혈성뇌졸중환자，의거림상표현화진단결과장기분위비진전성뇌졸중조(110례)화진전성뇌졸중조(90례)。채용채색다보륵초성진단의측량소유환자적경총동맥내막중층후도，병대량조환자적경총동맥내막중층후도이급입원급치료량주후적Hcy여Hs-CRP적수평진행비교。결과：경채색다보륵초성검사현시，진전성뇌졸중환자경내동맥혈관죽양반괴형성，혈관내막후도증가，혈관강변협착。진전성뇌졸중조적평균경총동맥내막중층후도위(1.54±0.39)mm，현저고우비진전성뇌졸중조(1.08±0.23)mm，차이유통계학의의(t=10.37，P＜0.05)；진전성뇌졸중조입원시급치료2주후적Hcy수평현저고우비진전성뇌졸중조，차이유통계학의의(t=5.104，P＜0.05)；진전성뇌졸중조입원시급치료2주후적Hs-CRP수평역현저고우비진전성뇌졸중조，차이유통계학의의(t=7.552，P＜0.05)。결론：혈청중적Hcy화Hs-CRP수평가작위평고결혈성뇌졸중예후적중요지표，결합채색다보륵초성진단기결과경위정학，치득림상추엄。
Objective:To explore the significance of homocysteine, high sensitivity C reactive protein (CRP) and Color Doppler ultrasound in ischemic stroke prognosis.Methods: Two hundred cases of ischemic stroke patients received in neurology department of our hospital from Jan 2012 to Jan 2015 were divided into non-progressive stroke group (110 cases of patients) and progressive stroke group (90 cases of patients) according to the clinical manifestations and diagnosis results of 200 patients. All common carotid artery intima-media thickness of all patients were measured by Color Doppler ultrasound. General information and carotid artery intima-media thickness in the two groups of patients were compared; homocysteine level and high-sensitivity C protein level in the two groups of patients on admission and after two weeks of treatment were compared.Results:Differences of general information between the two groups were not statistically significant (P>0.05); average carotid artery intima-media total thickness in progressive stroke group is (1.54±0.39)mm, significantly higher than non-progressive stroke group[(1.08±0.23) mm], the difference was statistically significant (t=10.37,P<0.05); Hcy levels in progressive stroke group on admitted to hospital and after two weeks’ treatment were significantly higher than non-progressive stroke group, the differences were statistically significant (t=3.343, 5.104,P<0.05); Hs-CRP levels in progressive stroke group on admitted day and after two weeks’ treatment were significantly higher than non-progressive stroke group, the differences were statistically significant (t=7.062, 7.552,P<0.05).Conclusion:Serum homocysteine levels and high-sensitivity C-reactive protein levels can be used as important indicators for prognostic evaluation of ischemic stroke, combining with Color Doppler ultrasound diagnosis can get more precise effect, and worthy of promotion.
