CAJ | 학술논문

反式脂肪酸是一类包含一个或多个反式构型双键的不饱和脂类分子。膳食中的反式脂肪酸有2类：微量的天然反式脂肪酸和可观的人造反式脂肪酸。过去的研究认为反式脂肪酸的摄入仅仅是一个营养问题，但越来越多的毒理学和暴露评估的研究结果表明反式脂肪酸对人体健康有诸多不良影响。因此，反式脂肪酸的摄入已成为一个食品安全问题。目前，许多国家已经对反式脂肪酸的摄入量做了规定。本文主要围绕膳食反式脂肪酸的来源、对人体产生的生理效应和病理影响、产生这些效应的细胞或分子机制，以及如何有效控制反式脂肪酸的摄入等进行综述，并讨论了反式脂肪酸的风险评估现状和未来展望。
반식지방산시일류포함일개혹다개반식구형쌍건적불포화지류분자。선식중적반식지방산유2류：미량적천연반식지방산화가관적인조반식지방산。과거적연구인위반식지방산적섭입부부시일개영양문제，단월래월다적독이학화폭로평고적연구결과표명반식지방산대인체건강유제다불량영향。인차，반식지방산적섭입이성위일개식품안전문제。목전，허다국가이경대반식지방산적섭입량주료규정。본문주요위요선식반식지방산적래원、대인체산생적생리효응화병리영향、산생저사효응적세포혹분자궤제，이급여하유효공제반식지방산적섭입등진행종술，병토론료반식지방산적풍험평고현상화미래전망。
Trans-fatty acids (TFA) are a class of unsaturated fatty acids containing one or more double bonds in the trans configuration. Two types of TFAs presented in our dietary foods: the minor naturally occurred and the major artificially added TFAs. Previous studies suggested that the intake of TFAs was only a nutritional problem, but a growing number of data from both toxicological studies and exposure assessment showed that TFAs had many adverse effects on human health. Therefore, intake of TFAs was actually becoming an issue of food safety. Currently, many countries have officially taken steps to restrain the intake of dietary TFA. This review summarized current progresses in the studies on dietary TFAs, including the sources of dietary TFAs, its physiological and pathological effects on human health, and its mitigation approaches, together with the current status of its risk assessment and future prospects.