CAJ | 학술논문

曲霉属真菌(Aspergillus)如黄曲霉、寄生曲霉侵染玉米、花生等富含油脂的作物种子后产生的黄曲霉毒素(aflatoxin)具有强致癌作用,严重威胁食品安全和人类健康。群体感应(quorum sensing, QS)曾经认为只存在于细菌中,但是在真菌中也存在 QS系统,菌体的形态建成和次级代谢产物的产生都与细胞的群体密度有关。黄曲霉拥有类似群体感应的机制,菌核到分生孢子的转换受细胞密度和脂肪氧合酶调控。氧脂素作为信号分子通过密度依赖机制可抑制或促进黄曲霉的生长及黄曲霉毒素的生物合成,本文综述了黄曲霉群体感应及信号通路的研究进展,旨在从群体感应的角度抑制黄曲霉毒素的产生,为微生物与食品安全的研究提供指导。
곡매속진균(Aspergillus)여황곡매、기생곡매침염옥미、화생등부함유지적작물충자후산생적황곡매독소(aflatoxin)구유강치암작용,엄중위협식품안전화인류건강。군체감응(quorum sensing, QS)증경인위지존재우세균중,단시재진균중야존재 QS계통,균체적형태건성화차급대사산물적산생도여세포적군체밀도유관。황곡매옹유유사군체감응적궤제,균핵도분생포자적전환수세포밀도화지방양합매조공。양지소작위신호분자통과밀도의뢰궤제가억제혹촉진황곡매적생장급황곡매독소적생물합성,본문종술료황곡매군체감응급신호통로적연구진전,지재종군체감응적각도억제황곡매독소적산생,위미생물여식품안전적연구제공지도。
Aspergillus spp such as A. flavus and A. parasiticus can infect oil-rich crop seeds and subsequently lead to aflatoxin contamination, which has an important impact on economic loss and health risk. Although once thought to exist only in bacteria, QS systems are now well established in fungi. Recently it has been shown that A. flavus possesses a quorum-sensing-like mechanism, where a sclerotia-to-conidia transition is governed by cell density and lipoxygenase activity. Oxylipins can inhibit or stimulate fungal development and aflatoxin production via a density-dependent mechanism as a kind of signal .This paper reviewed the research progress on quorum sensing and signaling pathways of A. flavus and was aimed to inhibit the generation of aflatoxin from the perspective of quorum sensing, providing a guidance for the research of microorganism and food safety.