中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
8期
1407-1409
,共3页
柴葛清热颗粒%抗炎%镇痛%解热
柴葛清熱顆粒%抗炎%鎮痛%解熱
시갈청열과립%항염%진통%해열
Chaige Qingre granules%Anti-inflammation%Analgesia%Relieving fever
目的：：研究柴葛清热颗粒的抗炎、镇痛、解热作用。方法：采用昆明种小鼠,以二甲苯致小鼠耳廓肿胀法对柴葛清热颗粒进行抗炎作用评价；以醋酸致小鼠扭体法对柴葛清热颗粒进行镇痛作用评价；采用酵母对Wistar大鼠致热法测定柴葛清热颗粒的解热作用。结果：柴葛清热颗粒对小鼠耳廓肿胀有显著抑制作用,高剂量时其抑制率为46.3%；柴葛清热颗粒中、高剂量组对小鼠疼痛有显著缓解作用,抑制率分别为51.1%,61.8%；大鼠体温上升1 h,柴葛清热颗粒低中高剂量组即对其体温有显著降低作用,高剂量组对发热大鼠降温达0.56℃。结论：柴葛清热颗粒能抑制小鼠耳廓肿胀,缓解小鼠疼痛,降低高热大鼠体温。
目的：：研究柴葛清熱顆粒的抗炎、鎮痛、解熱作用。方法：採用昆明種小鼠,以二甲苯緻小鼠耳廓腫脹法對柴葛清熱顆粒進行抗炎作用評價；以醋痠緻小鼠扭體法對柴葛清熱顆粒進行鎮痛作用評價；採用酵母對Wistar大鼠緻熱法測定柴葛清熱顆粒的解熱作用。結果：柴葛清熱顆粒對小鼠耳廓腫脹有顯著抑製作用,高劑量時其抑製率為46.3%；柴葛清熱顆粒中、高劑量組對小鼠疼痛有顯著緩解作用,抑製率分彆為51.1%,61.8%；大鼠體溫上升1 h,柴葛清熱顆粒低中高劑量組即對其體溫有顯著降低作用,高劑量組對髮熱大鼠降溫達0.56℃。結論：柴葛清熱顆粒能抑製小鼠耳廓腫脹,緩解小鼠疼痛,降低高熱大鼠體溫。
목적：：연구시갈청열과립적항염、진통、해열작용。방법：채용곤명충소서,이이갑분치소서이곽종창법대시갈청열과립진행항염작용평개；이작산치소서뉴체법대시갈청열과립진행진통작용평개；채용효모대Wistar대서치열법측정시갈청열과립적해열작용。결과：시갈청열과립대소서이곽종창유현저억제작용,고제량시기억제솔위46.3%；시갈청열과립중、고제량조대소서동통유현저완해작용,억제솔분별위51.1%,61.8%；대서체온상승1 h,시갈청열과립저중고제량조즉대기체온유현저강저작용,고제량조대발열대서강온체0.56℃。결론：시갈청열과립능억제소서이곽종창,완해소서동통,강저고열대서체온。
To investigate the anti-inflammatory, analgesia and antipyretic effects of Chaige Qingre granules. Meth-ods:Kunming mice were used to make auricle swelling model by dimthylphenanthrene, and the auricle swelling degree was measured to test the anti-inflammatory effect of Chaige Qingre granules. Mice were used to make pain models by acetic acid, and the body twis-ting of the mice was counted to observe the analgesia effect of the granules. The fever model in rats was induced by yeast, and the body temperature of the rats was measured to investigate the antipyretic effects of the granules. Results:Chaige Qingre granules could relieve the auricle swelling degree significantly, and the inhibition rate was 46. 3% in the high dose group. High and middle dose groups could reduce the body twisting frequency with the inhibition rate of 51. 1% and 61. 8%, respectively. Every Chaige Qingre granules group could lower the body temperature after one hour of the administration, and the temperature could be reduced 0. 56 degrees Celsius in the high dose group. Conclusion:Chaige Qingre granules can effectively inhibit auricle swelling degree, relieve pain and reduce heat.
