CAJ | 학술논문

目的：系统评价复方阿嗪米特联合胃肠动力药治疗功能性消化不良(FD)的疗效。方法通过中国知网(CNKI)，中国生物医学文献数据库(CBM)，PubMed，EMBASE，Cochrane Library 等数据库，检索有关复方阿嗪米特联合胃肠动力药对比单用胃肠动力药治疗 FD 的随机对照试验，应用 RevMan 5.3软件行 Meta 分析。结果共23个研究，包括2412例 FD 患者纳入分析。复方阿嗪米特联合胃肠动力药治疗 FD 的总有效率显著高于单用胃肠动力药( RR =1.38，95% CI =1.29－1.47)。各项研究均未报道严重不良反应。结论复方阿嗪米特联合胃肠动力药可明显提高 FD 的疗效，且安全性较高。
목적：계통평개복방아진미특연합위장동력약치료공능성소화불량(FD)적료효。방법통과중국지망(CNKI)，중국생물의학문헌수거고(CBM)，PubMed，EMBASE，Cochrane Library 등수거고，검색유관복방아진미특연합위장동력약대비단용위장동력약치료 FD 적수궤대조시험，응용 RevMan 5.3연건행 Meta 분석。결과공23개연구，포괄2412례 FD 환자납입분석。복방아진미특연합위장동력약치료 FD 적총유효솔현저고우단용위장동력약( RR =1.38，95% CI =1.29－1.47)。각항연구균미보도엄중불량반응。결론복방아진미특연합위장동력약가명현제고 FD 적료효，차안전성교고。
Objective To systematically evaluate the effect of combination therapy of compound azintamide and gastrointestinal prokinetic drug in patients with FD. Methods China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBM), PubMed, EMBASE and Cochrane Librarywas were retrieved to collect randomized controlled trials that compared the effect of compound azin-tamide plus gastrointestinal prokinetic drug with simplex gastrointestinal prokinetic drug. Meta - analysis was performed with RevMan 5. 3 software. Results Twenty - three studies involving 2 412 FD patients were enrolled. The total effective rate in treatment group was sig-nificantly higher than that in control group ( RR = 1. 38, 95% CI = 1. 29 - 1. 47) . All the studies had not report serious adverse events. Conclusion Combination therapy of compound azintamide and gastrointestinal prokinetic drug can improve the efficacy of FD with high safety. The findings should be interpreted cautiously due to low quality of included studies and potential biases.