中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
8期
1341-1342,1343
,共3页
双环醇%多烯磷酯酰胆碱%甲状腺机能亢进%肝损伤
雙環醇%多烯燐酯酰膽堿%甲狀腺機能亢進%肝損傷
쌍배순%다희린지선담감%갑상선궤능항진%간손상
Bicyclol%Polyene phosphatidylcholine%Hyperthyroidism%Liver Injury
目的：：观察双环醇片和多烯磷酯酰胆碱胶囊治疗甲亢性肝损伤临床疗效和安全性。方法：112例甲亢性肝损伤患者随机分为两组，在常规使用甲巯咪唑治疗同时，观察组56例加用双环醇片，对照组56例加用多烯磷酯酰胆碱胶囊，疗程均为4周。比较两组患者治疗前后丙氨酸转氨酶( ALT)、血清天冬氨酸转氨酶( AST)、总胆红素( TBIL)、碱性磷酸酶( ALP)等指标的变化，观察两组疗效与药品不良反应。结果：治疗后两组ALT、AST、TBIL、ALP水平均较治疗前显著下降(P<0.05)，且观察组ALT、AST水平明显低于对照组(P<0.05)，而TBIL、ALP水平无差异(P>0.05)。观察组总有效率明显高于对照组(P<0.05)。两组药品不良反应均较轻微。结论：双环醇片能有效治疗甲亢性肝损伤，且疗效优于多烯磷酯酰胆碱。
目的：：觀察雙環醇片和多烯燐酯酰膽堿膠囊治療甲亢性肝損傷臨床療效和安全性。方法：112例甲亢性肝損傷患者隨機分為兩組，在常規使用甲巰咪唑治療同時，觀察組56例加用雙環醇片，對照組56例加用多烯燐酯酰膽堿膠囊，療程均為4週。比較兩組患者治療前後丙氨痠轉氨酶( ALT)、血清天鼕氨痠轉氨酶( AST)、總膽紅素( TBIL)、堿性燐痠酶( ALP)等指標的變化，觀察兩組療效與藥品不良反應。結果：治療後兩組ALT、AST、TBIL、ALP水平均較治療前顯著下降(P<0.05)，且觀察組ALT、AST水平明顯低于對照組(P<0.05)，而TBIL、ALP水平無差異(P>0.05)。觀察組總有效率明顯高于對照組(P<0.05)。兩組藥品不良反應均較輕微。結論：雙環醇片能有效治療甲亢性肝損傷，且療效優于多烯燐酯酰膽堿。
목적：：관찰쌍배순편화다희린지선담감효낭치료갑항성간손상림상료효화안전성。방법：112례갑항성간손상환자수궤분위량조，재상규사용갑구미서치료동시，관찰조56례가용쌍배순편，대조조56례가용다희린지선담감효낭，료정균위4주。비교량조환자치료전후병안산전안매( ALT)、혈청천동안산전안매( AST)、총담홍소( TBIL)、감성린산매( ALP)등지표적변화，관찰량조료효여약품불량반응。결과：치료후량조ALT、AST、TBIL、ALP수평균교치료전현저하강(P<0.05)，차관찰조ALT、AST수평명현저우대조조(P<0.05)，이TBIL、ALP수평무차이(P>0.05)。관찰조총유효솔명현고우대조조(P<0.05)。량조약품불량반응균교경미。결론：쌍배순편능유효치료갑항성간손상，차료효우우다희린지선담감。
To observe the clinical efficacy and safety of bicyclol and polyene phosphatidylcholine in the treatment of liver injury induced by hyperthyroidism. Methods: Totally 112 cases of hyperthyroidism patients were randomly divided into two groups, and both groups were treated with antithyroid drug methimazole. The 56 patients in the treatment group were orally treated with bicyclol, and the other 56 patients in the control group received polyene phosphatidylcholine capsules orally. The changes of liver func-tion were compared before and after the 4-week treatment, including the level of alanine aminotransferase (ALT), aspartate amin-otransferase ( AST) , total bilirubin ( TBIL) and alkaline phosphatase ( ALP) . The efficacy and adverse reactions were also observed. Results:There was no difference in the levels of ALT, AST, TBIL and ALP in both groups before the treatment (P>0. 05), while the levels were all decreased significantly in both groups after the treatment (P<0. 05). Compared with those of the control group, ALT and AST levels of the treatment group were decreased significantly after the treatment (P<0. 05), and the total effective rate of the treatment group was higher than that of the control group with statistical significance (P <0.05), while no statistically significant difference was shown in the levels of TBIL and ALP (P>0. 05). No drug-related adverse events were shown during the treatment. Conclusion:Bicyclol is effective and reliable in the treatment of liver injury induced by hyperthyroidism, and the clinical efficacy is remarkable when compared with that of polyene phosphatidylcholine.
