CAJ | 학술논문

目的：：观察CAG方案治疗老年初治急性髓性细胞白血病的临床疗效。方法：35例老年急性髓性细胞白血病患者随机分为两组，对照组患者(15例)采用标准化疗方案治疗；CAG组患者(20例)采用CAG方案(阿糖胞苷、阿克拉霉素、粒细胞集落刺激因子)治疗。治疗一个疗程后观察患者化疗疗效，比较两组患者中性粒细胞和血小板恢复时间以及药品不良反应发生率。结果：CAG组患者的治疗有效率为90%，明显高于对照组患者的60%(P<0.05)。 CAG组患者的中性粒细胞和血小板恢复时间均明显短于对照组患者(P<0.05)。 CAG组不良反应总发生率明显低于对照组(P<0.05)。结论： CAG方案治疗35例老年初治急性髓性细胞白血病化疗效果良好，可有效控制病情发展，加速血细胞恢复，安全性高。
목적：：관찰CAG방안치료노년초치급성수성세포백혈병적림상료효。방법：35례노년급성수성세포백혈병환자수궤분위량조，대조조환자(15례)채용표준화료방안치료；CAG조환자(20례)채용CAG방안(아당포감、아극랍매소、립세포집락자격인자)치료。치료일개료정후관찰환자화료료효，비교량조환자중성립세포화혈소판회복시간이급약품불량반응발생솔。결과：CAG조환자적치료유효솔위90%，명현고우대조조환자적60%(P<0.05)。 CAG조환자적중성립세포화혈소판회복시간균명현단우대조조환자(P<0.05)。 CAG조불량반응총발생솔명현저우대조조(P<0.05)。결론： CAG방안치료35례노년초치급성수성세포백혈병화료효과량호，가유효공제병정발전，가속혈세포회복，안전성고。
To study the efficacy of CAG regimen used in 35 cases of newly diagnosed acute myeloid leukemia in elder-ly patients. Methods:Totally 35 cases of elderly patients with acute myeloid leukemia were randomly divided into two groups. The pa-tients in the control group (15 cases) were treated with standard chemotherapy treatment, while the CAG regimen group (20 cases) was treated with CAG regimen (cytarabine, aclarubicin and granulocyte colony-stimulating factor). After one treatment course, the chemotherapy efficacy was observed, and the neutrophil and platelet recovery time and the incidence of adverse reactions in the two groups were compared. Results:The treatment efficacy of the CAG regimen group was 90%, which was higher than that of the control group (60%, P<0. 05). The neutrophil and platelet recovery time of the CAG regimen group was significantly shorter than that of the control group (P<0. 05). The incidence of adverse reactions in CAG regimen group was much lower than that of the control group(P<0. 05). Conclusion:The efficacy of CAG regimen used in the 35 cases of newly diagnosed acute myeloid leukemia in elderly pa-tients is promising, which can effectively control the progression of the disease and accelerate blood cell recovery with high safety.