中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
8期
1355-1356,1357
,共3页
九味镇心颗粒%广泛性焦虑%汉密尔顿焦虑量表评分%坦度螺酮
九味鎮心顆粒%廣汎性焦慮%漢密爾頓焦慮量錶評分%坦度螺酮
구미진심과립%엄범성초필%한밀이돈초필량표평분%탄도라동
Jiuweizhenxin granules%Generalized anxiety disorder%HAMA score%Tandospirone
目的：：观察九味镇心颗粒治疗广泛性焦虑的有效性及安全性。方法：广泛性焦虑诊断患者按入院先后顺序分为联合用药组31例(九味镇心颗粒与坦度螺酮胶囊联用)、九味镇心组32例(单用九味镇心颗粒)、坦度螺酮组33例(单用坦度螺酮胶囊)。疗程均为4周。采用汉密尔顿焦虑量表( HAMA)分别于给药前,给药后第2、4、6周末进行评定,比较3组的临床疗效和药品不良反应。结果：治疗第4周后,3组HAMA评分较治疗前均有明显下降(P<0.01)；治疗第6周,联合用药组HA-MA评分明显低于其他两组(P<0.05),而其他两组间差异无统计学意义(P>0.05)。3组临床总有效率与药品不良反应发生率比较,差异均无统计学意义(P>0.05)。结论：九味镇心颗粒联合坦度螺酮胶囊治疗广泛性焦虑能更有效改善患者HAMA评分,疗效显著,且不增加不良反应,值得临床推广。
目的：：觀察九味鎮心顆粒治療廣汎性焦慮的有效性及安全性。方法：廣汎性焦慮診斷患者按入院先後順序分為聯閤用藥組31例(九味鎮心顆粒與坦度螺酮膠囊聯用)、九味鎮心組32例(單用九味鎮心顆粒)、坦度螺酮組33例(單用坦度螺酮膠囊)。療程均為4週。採用漢密爾頓焦慮量錶( HAMA)分彆于給藥前,給藥後第2、4、6週末進行評定,比較3組的臨床療效和藥品不良反應。結果：治療第4週後,3組HAMA評分較治療前均有明顯下降(P<0.01)；治療第6週,聯閤用藥組HA-MA評分明顯低于其他兩組(P<0.05),而其他兩組間差異無統計學意義(P>0.05)。3組臨床總有效率與藥品不良反應髮生率比較,差異均無統計學意義(P>0.05)。結論：九味鎮心顆粒聯閤坦度螺酮膠囊治療廣汎性焦慮能更有效改善患者HAMA評分,療效顯著,且不增加不良反應,值得臨床推廣。
목적：：관찰구미진심과립치료엄범성초필적유효성급안전성。방법：엄범성초필진단환자안입원선후순서분위연합용약조31례(구미진심과립여탄도라동효낭련용)、구미진심조32례(단용구미진심과립)、탄도라동조33례(단용탄도라동효낭)。료정균위4주。채용한밀이돈초필량표( HAMA)분별우급약전,급약후제2、4、6주말진행평정,비교3조적림상료효화약품불량반응。결과：치료제4주후,3조HAMA평분교치료전균유명현하강(P<0.01)；치료제6주,연합용약조HA-MA평분명현저우기타량조(P<0.05),이기타량조간차이무통계학의의(P>0.05)。3조림상총유효솔여약품불량반응발생솔비교,차이균무통계학의의(P>0.05)。결론：구미진심과립연합탄도라동효낭치료엄범성초필능경유효개선환자HAMA평분,료효현저,차불증가불량반응,치득림상추엄。
To explore the safety and efficacy of tandospirone combined with Jiuweizhenxin granules in the treatment of generalized anxiety disorder. Methods:The patients with generalized anxiety diagnosis were divided into three groups according to the admission order, the combination group(Jiuweizhenxin granules plus tandospirone), Jiuweizhenxin granules group and tandospirone group respectively with 31, 32 and 33 ones. The period of treatment was 4 weeks. All the patients were assessed for efficacy using Hamilton anxiety scale (HAMA). The adverse symptoms were observed before the treatment, in the 2nd, 4th and 6th week and after the treatment. The efficacy and adverse effects in the three groups were also observed. Results: After the 4-week treatment, HAMA score of the three groups was significantly lowered when compared with that before the treatment (P<0. 05). After the 6-week treat-ment, HAMA score of the combination group was significantly lower than that of the other two groups (P>0. 05). The clinical total ef-fective rate and the incidence of adverse drug reactions in the three groups showed no statistically significant difference (P>0. 05). Conclusion:Tandospirone combined with Jiuweizhenxin granules in the treatment of generalized anxiety can effectively improve HAMA score with promising curative effect and adverse reactions, which is worthy of clinical promotion.
