CAJ | 학술논문

目的：：评价珍菊降压片联合长效降压药物治疗高血压的疗效和安全性。方法：220例高血压患者随机分为观察组和对照组各110例。两组患者均维持原服用的长效降压药物,qd。观察组口服珍菊降压片(0.25 g,bid),对照组口服珍菊降压片模拟片(每次1片,bid),共治疗4周。以治疗后的血压降低幅度、高血压临床症状积分、动态血压监测指标等评价临床疗效。通过症状、体征、实验室检查等评价药物安全性。结果：治疗4周后,两组收缩压、舒张压均较治疗前显著下降(P<0.01),且观察组下降值明显高于对照组(P<0.01)；两组高血压临床症状总评分均较治疗前明显下降(P<0.01),且观察组症状评分下降值明显高于对照组(P<0.01),观察组高血压临床症状疗效整体优于对照组(P<0.01)；两组24 h、白昼、夜间的平均收缩压、舒张压以及血压非正常值的次数等指标比较,差异无统计学意义(P>0.05),但观察组24 h平均收缩压、白昼平均收缩压与治疗前相比有统计学意义(P<0.05),对照组组内治疗前后相比无统计学意义(P>0.05),观察组24h及白昼血压非正常次数有下降趋势。两组药品不良反应发生率差异无统计学意义(P>0.05)。结论：在长效降压药物基础上加用珍菊降压片能进一步提高降压疗效,无明显不良反应,适合临床应用。
목적：：평개진국강압편연합장효강압약물치료고혈압적료효화안전성。방법：220례고혈압환자수궤분위관찰조화대조조각110례。량조환자균유지원복용적장효강압약물,qd。관찰조구복진국강압편(0.25 g,bid),대조조구복진국강압편모의편(매차1편,bid),공치료4주。이치료후적혈압강저폭도、고혈압림상증상적분、동태혈압감측지표등평개림상료효。통과증상、체정、실험실검사등평개약물안전성。결과：치료4주후,량조수축압、서장압균교치료전현저하강(P<0.01),차관찰조하강치명현고우대조조(P<0.01)；량조고혈압림상증상총평분균교치료전명현하강(P<0.01),차관찰조증상평분하강치명현고우대조조(P<0.01),관찰조고혈압림상증상료효정체우우대조조(P<0.01)；량조24 h、백주、야간적평균수축압、서장압이급혈압비정상치적차수등지표비교,차이무통계학의의(P>0.05),단관찰조24 h평균수축압、백주평균수축압여치료전상비유통계학의의(P<0.05),대조조조내치료전후상비무통계학의의(P>0.05),관찰조24h급백주혈압비정상차수유하강추세。량조약품불량반응발생솔차이무통계학의의(P>0.05)。결론：재장효강압약물기출상가용진국강압편능진일보제고강압료효,무명현불량반응,괄합림상응용。
To determine the efficacy and safety of Zhenjujiangya tablets combined with long-acting antihypertensive drugs in the patients with hypertension. Methods:A controlled study was carried out among 220 patients meeting the inclusion / ex-clusion criteria. All the patients were randomly divided into the experimental group and the control group. Both groups were treated with long-acting antihypertensive drugs as usual. The 110 patients in the experimental group were orally treated with Zhenjujiangya tab-lets ( bid) , while the other 110 patients in the control group were orally treated with Zhenjujiangya simulated tablets ( bid) , and the treatment course was 4 weeks. The efficacy was assessed using the reduction range of blood pressure, the clinical symptom score of hy-pertension and the indicators of ambulatory blood pressure monitoring as the indices, and the safety was assessed by the symptoms, signs and laboratory tests. Results:After the four-week treatment, the systolic blood pressure, diastolic blood pressure and hyperten-sion clinical symptom score were significantly decreased in the two groups, and the changes in the experimental group were more signifi-cant than those in the control group (P<0. 01). The effect on the clinical symptom of the experimental group was better than that of the control group (P<0. 01). There was no significant difference in systolic blood pressure, diastolic blood pressure and the number of abnormal blood pressure in 24h, daytime and nighttime (P>0. 05). After the treatment, the changes in average systolic blood pres-sure in 24h and daytime in the experimental group showed statistically significant difference (P<0.05),while those in the control group were without statistically significant difference (P>0. 05), and the number of abnormal blood pressure in 24h and daytime in the experimental group exhibited reduction trend. There were no significant difference in the incidence of adverse events between the two groups (P>0. 05). Conclusion:Long-acting antihypertensive drugs combined with Zhenjujiangya tablets can further improve the antihypertensive efficacy without significant adverse reactions, which is suitable for clinical application.