食品研究与开发
食品研究與開髮
식품연구여개발
FOOD RESEARCH AND CEVELOPMENT
2015年
15期
124-128
,共5页
郭霄%张勇%高鹏飞%姚国强%孙天松
郭霄%張勇%高鵬飛%姚國彊%孫天鬆
곽소%장용%고붕비%요국강%손천송
功能性食品%胆固醇7α-羟化酶%降胆固醇
功能性食品%膽固醇7α-羥化酶%降膽固醇
공능성식품%담고순7α-간화매%강담고순
functional food%cholesterol 7-alpha hydroxylase%cholesterol-lowering
胆固醇7α-羟化酶（Cholesterol 7-alpha hydroxylase，CYP7A1）在维持胆固醇代谢动态平衡时起重要的作用。通过概述CYP7A1的调控机制，综述近年来报道的益生菌、膳食纤维、多酚类物质等功能性食品对CYP7A1基因表达的调节和影响，展望以CYP7A1为靶点的降胆固醇功能性食品的开发前景，旨在为筛选以CYP7A1为靶点的功能性食品提供参考。
膽固醇7α-羥化酶（Cholesterol 7-alpha hydroxylase，CYP7A1）在維持膽固醇代謝動態平衡時起重要的作用。通過概述CYP7A1的調控機製，綜述近年來報道的益生菌、膳食纖維、多酚類物質等功能性食品對CYP7A1基因錶達的調節和影響，展望以CYP7A1為靶點的降膽固醇功能性食品的開髮前景，旨在為篩選以CYP7A1為靶點的功能性食品提供參攷。
담고순7α-간화매（Cholesterol 7-alpha hydroxylase，CYP7A1）재유지담고순대사동태평형시기중요적작용。통과개술CYP7A1적조공궤제，종술근년래보도적익생균、선식섬유、다분류물질등공능성식품대CYP7A1기인표체적조절화영향，전망이CYP7A1위파점적강담고순공능성식품적개발전경，지재위사선이CYP7A1위파점적공능성식품제공삼고。
Cholesterol 7-alpha hydroxylase (CYP7A1) have been shown to play an important role in maintaining cholesterol metabolism homeostasis. This review outlined the mechanisms underlying regulation of CYP7A1, the functional food which includes probiotics, dietary fiber and polyphenols affecting CYP7A1 and the regulation of gene expression were summarized. In addition , the development prospect of the cholesterol-lowering functional food targeting CYP7A1 was analyzed. The aim of this review was to provide clues in screening to CYP7A1 targets of functional food.
