CAJ | 학술논문

缺铁性贫血是当前发病率最高的营养素缺乏病之一，补充足量的铁是防治缺铁性贫血最根本的方法。因此，高生物利用度的铁营养强化剂一直是人们研究的热点。目前广泛使用的铁补充剂分为无机铁和有机铁两类。无机铁的代表是硫酸亚铁，其补铁效果虽好，但具有明显的副作用，如胃肠道刺激、口腔异味以及铁中毒等。研究表明，多糖铁复合物作为一种有机铁化合物，对胃肠道刺激小、生物利用度高，是目前比较有效的缺铁性贫血的补铁剂，因此受到越来越广泛的关注。本文围绕多糖铁复合物的制备方法、铁含量测定方法、结构分析、理化性质、吸收性质和临床应用方面展开综述。多糖铁复合物的结构确证和安全性、多糖的结构和种类对多糖铁复合物有效性的影响以及如何进一步提高多糖铁复合物的有效性需要做进一步的研究。
결철성빈혈시당전발병솔최고적영양소결핍병지일，보충족량적철시방치결철성빈혈최근본적방법。인차，고생물이용도적철영양강화제일직시인문연구적열점。목전엄범사용적철보충제분위무궤철화유궤철량류。무궤철적대표시류산아철，기보철효과수호，단구유명현적부작용，여위장도자격、구강이미이급철중독등。연구표명，다당철복합물작위일충유궤철화합물，대위장도자격소、생물이용도고，시목전비교유효적결철성빈혈적보철제，인차수도월래월엄범적관주。본문위요다당철복합물적제비방법、철함량측정방법、결구분석、이화성질、흡수성질화림상응용방면전개종술。다당철복합물적결구학증화안전성、다당적결구화충류대다당철복합물유효성적영향이급여하진일보제고다당철복합물적유효성수요주진일보적연구。
Iron deficiency anemia (IDA) is one of the highest incidence of nutrient deficiency diseases, and the most basic method to prevent iron deficiency anemia is to take enough iron. Therefore, high biological utilization of iron fortifiers has always been the focus of study. At present, the popular iron supplements include two types, inorganic iron and organic iron. Ferrous sulfate is the representative of inorganic iron. Although it is an effective iron supplement, it has a lot of side effects, such as gastrointestinal irritation, oral odor and iron poisoning, etc. Many research showed that the polysaccharide-iron complex, as a kind of organic iron compound, with high bioavailability but little gastrointestinal irritation, is a kind of more effective iron supplement to prevent iron deficiency anemia, so it has been attracting more and more attention. This article mainly discussed the preparation methods of polysaccharide-iron complex, the determination methods of iron content, structural analysis, physical and chemical properties, absorption properties and its clinical applications. In addition, the influence of polysaccharide’s type and structure on the efficacy, the structure confirmation and safety of polysaccharide-iron compound, as well as how to improve the efficacy of polysaccharide-iron compound need further research.