CAJ | 학술논문

目的：：研究不同产地冬虫夏草对CCl4所致急性肝损伤的保护作用。方法：建立CCl4诱导大鼠急性肝损伤模型,检测各组大鼠血清天门冬氨酸转氨酶( AST)、丙氨酸转氨酶( ALT)以及肝脏组织匀浆超氧化物歧化酶( SOD)、谷脱甘肽过氧化物酶( GSH)等各项生化指标,HE染色观察各组大鼠肝脏病理状况。结果：与模型组相比,不同产地虫草低、中、高三个剂量组均能显著降低大鼠血清AST、ALT水平,升高肝组织匀浆SOD、GSH水平(P>0.05),改善肝细胞坏死程度,但两个不同产地间的差异并不显著(P>0.05)。结论：青海和西藏两个产地冬虫夏草对CCl4所致大鼠急性肝损伤均有一定的保护作用,但无明显差异。
목적：：연구불동산지동충하초대CCl4소치급성간손상적보호작용。방법：건립CCl4유도대서급성간손상모형,검측각조대서혈청천문동안산전안매( AST)、병안산전안매( ALT)이급간장조직균장초양화물기화매( SOD)、곡탈감태과양화물매( GSH)등각항생화지표,HE염색관찰각조대서간장병리상황。결과：여모형조상비,불동산지충초저、중、고삼개제량조균능현저강저대서혈청AST、ALT수평,승고간조직균장SOD、GSH수평(P>0.05),개선간세포배사정도,단량개불동산지간적차이병불현저(P>0.05)。결론：청해화서장량개산지동충하초대CCl4소치대서급성간손상균유일정적보호작용,단무명현차이。
To study and compare the protective effects of Cordyceps sinensis from different habitats on acute injury of hepatic tissue induced by carbon tetrachloride ( CCl4 ) . Methods:The rat model of acute injury of hepatic tissue induced by CCl4 was established. The biochemical indicators of alanine aminotranferease ( ALT) and aspartate aminotransferease ( AST) in the serum and superoxide dismutase ( SOD) and L-glutathione( GSH) in the liver tissue were detected, and the liver tissue HE staining was used for the histopathology determination. Results:Compared with those in the model group, the levels of AST and ALT in the serum were sig-nificantly reduced, the levels of SOD and GSH in the liver tissue were notably increased, and the necrosis of liver cells was improved in Cordyceps sinensis groups at low, medium and high dose from different habitats (P<0. 05), however, the differences between the two different habitats were not significant (P>0. 05). Conclusion: Cordyceps sinensis from Qinghai and Tibet shows some positive differences in the protective effect on the acute chemical liver injury induced by CCl4 in rats,however, the differences are not remarka-ble.