CAJ | 학술논문

目的观察左卡尼汀与重组人促红细胞生成素(rHuEPO)联合应用对维持性血液透析患者肾性贫血的改善作用.方法将40例维持性血液透析患者随机分为2组,治疗组20例,对照组20例.两组患者均接受标准剂量的升血治疗,血液透析后予促红细胞生成素皮下注射.同时,治疗组每次透析回血前予左卡尼汀1.0g静脉注射.2组疗程均为16周.检测并比较治疗前、治疗8周后、16周后2组患者外周血血红蛋白、红细胞压积、血压水平.结果 2组治疗8周、16周后患者外周血血红蛋白、红细胞压积均较治疗前有改善,差异有统计学意义(P＜0.05).与对照组比较,治疗组8周后血红蛋白、红细胞压积升高更明显,差异有统计学意义(P＜0.05);16周后2组间上述指标差异均无统计学意义(P＞0.05).与对照组比较,治疗组8周后、16周后高血压发生率较低.结论左卡尼汀可以辅助改善维持性血液透析患者肾性贫血,缩短纠正贫血时间,减少促红细胞生成素(EPO)使用剂量,从而可减少EPO相关不良反应.
목적 관찰좌잡니정여중조인촉홍세포생성소(rHuEPO)연합응용대유지성혈액투석환자신성빈혈적개선작용.방법 장40례유지성혈액투석환자수궤분위2조,치료조20례,대조조20례.량조환자균접수표준제량적승혈치료,혈액투석후여촉홍세포생성소피하주사.동시,치료조매차투석회혈전여좌잡니정1.0g정맥주사.2조료정균위16주.검측병비교치료전、치료8주후、16주후2조환자외주혈혈홍단백、홍세포압적、혈압수평.결과 2조치료8주、16주후환자외주혈혈홍단백、홍세포압적균교치료전유개선,차이유통계학의의(P＜0.05).여대조조비교,치료조8주후혈홍단백、홍세포압적승고경명현,차이유통계학의의(P＜0.05);16주후2조간상술지표차이균무통계학의의(P＞0.05).여대조조비교,치료조8주후、16주후고혈압발생솔교저.결론 좌잡니정가이보조개선유지성혈액투석환자신성빈혈,축단규정빈혈시간,감소촉홍세포생성소(EPO)사용제량,종이가감소EPO상관불량반응.
Objective To ovserve the effects of L-carnitine with rHuEPO on renal anemia in maintenance hemodialysis patients.Methods A total of 40 patients with renal anemia undergoing maintenance hemodialysis were randomly divided into two groups,treatment group (20 cases) and control group (20 cases).All the patients received conventional anemia correction treatment,recombinant erythropoietin,subcutaneous injection after hemodialysis.Patients in the treatment group were given Lcarnitine 1.0 g before the end of each hemodialysis.Treatment course was 16 weeks.Peripheral blood hemoglobin,HCT and blood pressure levels of the patients in these two groups were compared before and after 8 weeks'and 16 weeks' treatment.Results Peripheral blood hemoglobin and HCT of the patients in the two groups after treatment were obviously improved compared with baselines (P ＜ 0.05).Peripheral blood hemoglobin and HCT of the patients in the treatment group were increased significantly compared with the control group after 8 weeks' treatment(P ＜ 0.05);but changed insignificantly after 16 weeks'treatment.The incidence of high blood pressure was lower in the treatment group than in the control group both after 8 weeks' and after 16 weeks'treatment.Conclusion L-carnitine can increased the effect of recombinant erythropoietin on renal anemia in maintenance hemodialysis patients,shorten the period of treatment,reduce the dose of rHuEPO,reduce adverse reactions.