CAJ | 학술논문

目的：对重复经颅磁刺激（rTMS）合并度洛西汀治疗抑郁症进行探讨，研究其临床疗效及副作用。方法将84例抑郁症患者随机分为观察组和对照组，每组各42例，研究组给予rTMS真刺激，对照组给予rT M S假刺激，对右侧前额叶进行刺激（都给予5赫兹，连续4.9秒的刺激；每两次间隔30s，每次治疗给予10次刺激，10次一个疗程，持续28天）。合并给予度洛西汀，于治疗前及治疗28天后后应用汉密尔顿抑郁量表（HAMD）及不良反应量表（TESS）对比两组的疗效不良反应。结果观察组治疗后的HAMD评分下降明显，与假刺激组相比存在统计学差异（P＜0.05），不良反应轻微。结论重复经颅磁刺激（rTMS）合并度洛西汀治疗抑郁症效果好，无副反应。
목적：대중복경로자자격（rTMS）합병도락서정치료억욱증진행탐토，연구기림상료효급부작용。방법장84례억욱증환자수궤분위관찰조화대조조，매조각42례，연구조급여rTMS진자격，대조조급여rT M S가자격，대우측전액협진행자격（도급여5혁자，련속4.9초적자격；매량차간격30s，매차치료급여10차자격，10차일개료정，지속28천）。합병급여도락서정，우치료전급치료28천후후응용한밀이돈억욱량표（HAMD）급불량반응량표（TESS）대비량조적료효불량반응。결과관찰조치료후적HAMD평분하강명현，여가자격조상비존재통계학차이（P＜0.05），불량반응경미。결론중복경로자자격（rTMS）합병도락서정치료억욱증효과호，무부반응。
Objective To explore the efficacy and safety of repetitive transcranial magnetic stimulation(rTMS)combining with duloxetine in the treatment of depression. Methods Thirty patients with TRD were randomly divided into a real rTMS group and a sham rTMS group,both with Mirtazapine treatment.Each patient in the real rTMS group received 20 rTMS sessions over 4 weeks to the left dorsolateral prefrontal cortex.Hamilton Depression Scale(HAMD)and treatment emergent symptom scale( TESS) were used to assess the therapeutic effect of two treatment methods at baseline and at 4 weeks after treatment.Adverse reactions were observed and recorded in a 4 weeks'duration.Results There was significant improvement in the real rTMS group,as measured by scores on the HAMD and TESS.The difference between the real rTMS group and the sham rTMS group was significant(P<0.05).There was no serious adverse reaction.Conclusions As an effective and safe treatment for treatment-resistant depression,repetitive transcranial magnetic stimulation(rTMS)combining with Mirtazapine has broad application prospects.