中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2015年
20期
10-12
,共3页
膜性肾病%雷公藤%泼尼松
膜性腎病%雷公籐%潑尼鬆
막성신병%뢰공등%발니송
Idiopathic membranous nephropathy%Tripterygium wilfordii%Prednisone
目的:观察探讨雷公藤多甙片(Tripterygium Wilfordii,TW)联合半量激素(泼尼松)治疗原发性膜性肾病(Idiopathic Membranous Nephropathy,IMN)的临床疗效与安全性。方法:选取明确诊断为IMN的患者30例,给予TW(120mg/d)和泼尼松(30mg/d),并逐渐减量,同时给予补钙、调脂、抗血小板聚集等对症治疗,记录患者3个月、6个月、12个月的24h尿蛋白、血浆白蛋白(ALB)、血胆固醇(TC)、甘油三酯(TG)、谷丙转氨酶(ALT)、血肌酐(Scr)等相关生化指标,动态观察其临床疗效。结果:3个月时24h尿蛋白、TC、TG均有所下降,ALB有所提升,ALT、Scr基本无变化,6个月时各项指标较3个月时明显好转,12个月时各项指标均基本正常。结论:运用TW和半量激素(泼尼松)治疗IMN效果良好,患者耐受性较好,不良反应较少,是一种比较有效的治疗方法。
目的:觀察探討雷公籐多甙片(Tripterygium Wilfordii,TW)聯閤半量激素(潑尼鬆)治療原髮性膜性腎病(Idiopathic Membranous Nephropathy,IMN)的臨床療效與安全性。方法:選取明確診斷為IMN的患者30例,給予TW(120mg/d)和潑尼鬆(30mg/d),併逐漸減量,同時給予補鈣、調脂、抗血小闆聚集等對癥治療,記錄患者3箇月、6箇月、12箇月的24h尿蛋白、血漿白蛋白(ALB)、血膽固醇(TC)、甘油三酯(TG)、穀丙轉氨酶(ALT)、血肌酐(Scr)等相關生化指標,動態觀察其臨床療效。結果:3箇月時24h尿蛋白、TC、TG均有所下降,ALB有所提升,ALT、Scr基本無變化,6箇月時各項指標較3箇月時明顯好轉,12箇月時各項指標均基本正常。結論:運用TW和半量激素(潑尼鬆)治療IMN效果良好,患者耐受性較好,不良反應較少,是一種比較有效的治療方法。
목적:관찰탐토뢰공등다대편(Tripterygium Wilfordii,TW)연합반량격소(발니송)치료원발성막성신병(Idiopathic Membranous Nephropathy,IMN)적림상료효여안전성。방법:선취명학진단위IMN적환자30례,급여TW(120mg/d)화발니송(30mg/d),병축점감량,동시급여보개、조지、항혈소판취집등대증치료,기록환자3개월、6개월、12개월적24h뇨단백、혈장백단백(ALB)、혈담고순(TC)、감유삼지(TG)、곡병전안매(ALT)、혈기항(Scr)등상관생화지표,동태관찰기림상료효。결과:3개월시24h뇨단백、TC、TG균유소하강,ALB유소제승,ALT、Scr기본무변화,6개월시각항지표교3개월시명현호전,12개월시각항지표균기본정상。결론:운용TW화반량격소(발니송)치료IMN효과량호,환자내수성교호,불량반응교소,시일충비교유효적치료방법。
Objective: To observe and explore clinical efficacy and security of tripterygium wilfordii plus half amount of hormones (prednisone) in treating idiopathic membranous nephropathy. Methods: 30 patients diagnosed with IMN were given TW (120mg/d) plus prednisone(30mg/d),and slowly reducing the quantity, while giving calcium, lipid-lowering, anti-platelet aggregation and other symptomatic treatment, noted hydration therapy, recorded patients 3 months, 6 months,12 months’24h urinary protein, serum albumin (ALB), blood cholesterol (TC), triglycerides (TG), alanine transaminase (ALT), serum creatinine (Scr) and other biochemical markers while observing clinical efficacy dynamicly. Results: 3 months 24h urinary protein?TC?TG were dropped,ALB were raised, ALT, Scr without changing, 6 months the indicators were significantly higher compared to 3 months, indicators of patients were basically normal in 12 months. Conclusion: TW plus half amount of hormone (prednisone) was effective in treating IMN, with better tolerance and seldom side effects,it was a more effective method of treatment.