CAJ | 학술논문

目的：观察人工虫草多糖对肾病综合征模型大鼠的治疗效果。方法：雄性SD大鼠尾静脉注射阿霉素，建立大鼠肾病综合征模型，分为模型组、激素组、人工虫草多糖大、小剂量组及正常对照组。连续药物灌胃21d后观察各组大鼠一般情况，检测24h尿蛋白水平，取血测定血清白蛋白、总胆固醇、甘油三酯、尿素氮、肌酐。结果：与模型组比较，各药物组24h尿蛋白水平均显著降低，人工虫草多糖大及小剂量组能显著降低血清胆固醇及甘油三酯水平，提高血清白蛋白水平。结论：人工虫草多糖能改善阿霉素肾病大鼠生存质量，减轻尿蛋白丢失，提高白蛋白水平，降低胆固醇及甘油三酯水平，并有一定量效关系。
목적：관찰인공충초다당대신병종합정모형대서적치료효과。방법：웅성SD대서미정맥주사아매소，건립대서신병종합정모형，분위모형조、격소조、인공충초다당대、소제량조급정상대조조。련속약물관위21d후관찰각조대서일반정황，검측24h뇨단백수평，취혈측정혈청백단백、총담고순、감유삼지、뇨소담、기항。결과：여모형조비교，각약물조24h뇨단백수평균현저강저，인공충초다당대급소제량조능현저강저혈청담고순급감유삼지수평，제고혈청백단백수평。결론：인공충초다당능개선아매소신병대서생존질량，감경뇨단백주실，제고백단백수평，강저담고순급감유삼지수평，병유일정량효관계。
Objective: To observe the therapeutic effects of cordyceps polysaccharide on rat model of nephrotic syndrome induced by adriamycin. Methods: Rat models of nephritic syndrome were established by tail intravenous of adriamycin; model rats were randomly divided into the following groups: the model group, the glucocorticoid group, the cordyceps polysaccharide group of high dose, the cordyceps polysaccharide group of low dose. Intragastric administration was performed continually for 21 days. 24h urinary protein of all rats was determined at the 21st day. Then all animals were sacrificed to measured serum albumin, total cholesterol, triglyceride, blood urea nitrogen and creatinine. Results: Compared with the model group, 24h urinary protein levels in three treated groups were significantly decreased; the levels of serum total cholesterol and triglycerin in two cordyceps polysaccharide groups were obviously lower than those in the model group; and the levels of serum albumin were significantly more increased than model group. Conclusion: Cordyceps polysaccharide is effective in the treatment of chronic kidney disease in rat induced by adriamycin, decreased the contents of 24-hour urinary protein and serum lipid level, increased serum albumin level, and had dose-effect relationship.