CAJ | 학술논문

目的：观察刺五加皂苷对D-半乳糖所致衰老大鼠学习记忆功能和海马CA1区LTP的影响，探讨其可能的机制。方法：将27只大鼠随机分为对照组、D-半乳糖组和ASS组。D-半乳糖注射建立衰老大鼠模型，ASS组腹腔注射ASS干预。水迷宫检测大鼠的学习记忆能力。电生理实验比较强直刺激前后海马CA1区PS幅度变化。结果：在水迷宫实验中，ASS能明显改善衰老大鼠的学习记忆功能。电生理实验中，模型组强直刺激后平均PS增幅明显低于对照组，ASS组中衰老大鼠的PS增幅提高。结论：ASS能提高衰老大鼠的学习记忆能力，并改善D-半乳糖对大鼠海马CA1区LTP的抑制。
목적：관찰자오가조감대D-반유당소치쇠로대서학습기억공능화해마CA1구LTP적영향，탐토기가능적궤제。방법：장27지대서수궤분위대조조、D-반유당조화ASS조。D-반유당주사건립쇠로대서모형，ASS조복강주사ASS간예。수미궁검측대서적학습기억능력。전생리실험비교강직자격전후해마CA1구PS폭도변화。결과：재수미궁실험중，ASS능명현개선쇠로대서적학습기억공능。전생리실험중，모형조강직자격후평균PS증폭명현저우대조조，ASS조중쇠로대서적PS증폭제고。결론：ASS능제고쇠로대서적학습기억능력，병개선D-반유당대대서해마CA1구LTP적억제。
Objective: To observe the effects of ASS on learning and memory capability and LTP in hippocampal CA1 area of the aging rats induced by D-galactose. Methods: 27 SD rats were randomized into 3 groups. The models of aging rats were given injecting D-galactose (120mg·kg-1·d-1). The rats in the ASS group were treated with ASS solution (5mg·kg-1·d-1, IP ); the rats in the control group were treated with the same dose of saline. After 42 days, the learning and memory capability were detected in Morris water maze; electrophysiological method was used to observe the LTP in hippocampal CA1 area. Results: The Morris water maze test showed that ASS significantly improved learning and memory performance in aging rats. In the electrophysiological experiments, PS amplitude significantly decreased in model group versus control, and ASS treatment restored PS amplitude. Conclusion: ASS can improve learning and memory ability and LTP in the hippocampal CA1 of aging rats, and this effect could be attributed to improvement of synaptic dysfunction.