CAJ | 학술논문

目的：通过检测缺铁性贫血（ID A ）患者血清动脉粥样硬化相关的脂质代谢指标及脂蛋白相关磷脂酶A2（Lp‐PLA2）的水平，探讨IDA是否存在动脉粥样硬化的风险。方法选取IDA患者（80例）和健康对照者（80例）为研究对象，检测血清脂代谢相关指标及Lp‐PLA2水平，并进行组间比较，分析其相关性。结果 IDA组的TG水平高于健康对照组（0．99±0．26和0．83±0．26mmol／L，P＜0．05），HDL‐C水平低于健康对照组（1．5±0．2和1．7±0．3，P＜0．01）。IDA组血清Lp‐PLA2活性（36．4±5．6和33．33±5．9μmol／min／L ，P＜0．05）和含量（128±34和111±31 ng／mL ，P＜0．05）高于健康对照组。Lp‐PLA2活性和含量与血红蛋白浓度呈负相关（r＝－0．29／r＝－0．33，P＜0．05），与 HDL‐C呈负相关（r＝－0．38／r＝－0．35，P＜0．05），与LDL‐C呈正相关（r＝0．41／r＝0．36， P＜0．05）。结论 IDA患者体内存在脂质代谢异常，血清Lp‐PLA2水平明显升高，可能存在动脉粥样硬化的风险。
목적：통과검측결철성빈혈（ID A ）환자혈청동맥죽양경화상관적지질대사지표급지단백상관린지매A2（Lp‐PLA2）적수평，탐토IDA시부존재동맥죽양경화적풍험。방법선취IDA환자（80례）화건강대조자（80례）위연구대상，검측혈청지대사상관지표급Lp‐PLA2수평，병진행조간비교，분석기상관성。결과 IDA조적TG수평고우건강대조조（0．99±0．26화0．83±0．26mmol／L，P＜0．05），HDL‐C수평저우건강대조조（1．5±0．2화1．7±0．3，P＜0．01）。IDA조혈청Lp‐PLA2활성（36．4±5．6화33．33±5．9μmol／min／L ，P＜0．05）화함량（128±34화111±31 ng／mL ，P＜0．05）고우건강대조조。Lp‐PLA2활성화함량여혈홍단백농도정부상관（r＝－0．29／r＝－0．33，P＜0．05），여 HDL‐C정부상관（r＝－0．38／r＝－0．35，P＜0．05），여LDL‐C정정상관（r＝0．41／r＝0．36， P＜0．05）。결론 IDA환자체내존재지질대사이상，혈청Lp‐PLA2수평명현승고，가능존재동맥죽양경화적풍험。
Objective Detection of the lipid‐related atherogenic risk factors and the serum level of lipoprotein‐associated phospholipase A2(Lp‐PLA2)in iron deficiency anemia patients ,to explore whether IDA is the risk factor of atherogenic .Methods Eighty IDA women were compared with the healthy age‐matched controls .Lipoprotein pro‐file and level of Lp‐PLA2 were measured and evaluated .Results Triglycerides(0 .99 ± 0 .26 vs .0 .83 ± 0 .26 mmol/L , P<0 .05)were higher and HDL‐C(1 .5 ± 0 .2 vs .1 .7 ± 0 .3 ,P<0 .01)lower in the patients group .In IDA patients ,the Lp‐PLA2 mass and activity were increased ,correlated negatively with hemoglobin and HDL‐C ,while positively asso‐ciated with LDL‐C .Conclusion The alterations in lipoprotein profile ,and level of Lp‐PLA2 described in the present study indicate that non‐treated IDA might represent a proatherogenic state .